Epigenetic regulation in psychiatric disorders

By Nadia M. Tsankova, W. Renthal, Arvind Kumar, E. Nestler. Nature Reviews Neuroscience, 2007

1,384 citations recorded by the source corpus.

Subfields: Computer Networks and Communications, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/a5ddeff2589ea4631e2bb6e72969d703e25e803b

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Citations in the corpus

Synaptic plasticity and addiction (2007, background): “is how drug-induced gene transcription and epigenetic regulatio”
Major depressive disorder. (2008, neutral): “as histone codes for transcriptional activation, at the BDNF promoter region [49].”
Understanding resilience (2013, background): “Epigenetic differences can be a consequence of exposure to stress-related factors during critical periods of development, and hence contribute to susceptibility to psychiatric disorders (Tsankova et al., 2007; Dudley et al., 2011).”
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy (2008, background): “One potential mechanism whereby stress can influence fetal development and programming is through epigenetics, including DNA methylation (Seckl and Meaney, 2004; Weaver et al., 2004b; Tsankova et al., 2007).”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Recent studies have begun to address how epigenetic mechanisms, which modify gene expression without alter- ing the DNA code may have long-lasting effects in mature neurons that could be relevant to complex neurological and neuropsychiatric disorders (Tsankova et al, 2007).”
Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “In animal models, systemically or locally administered HDAC inhibitors display antidepressant properties without obvious adverse effects on health (12,79), suggesting that HDAC inhibitors may function by modulating a global acetylation/ deacetylation balance across several brain regions.”
Psychobiology and molecular genetics of resilience (2009, neutral): “Epigenetics refers to stable changes in chromatin structure that underlie long-lasting alterations in gene expression and that are not associated with changes in DNA sequenc”
Neuronal activity modifies DNA methylation landscape in the adult brain (2011, background): “Emerging evidence suggests the importance of epigenetic regulation in activity-dependent mature brain function”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “…recent studies suggest that comparable epigenetic modifications associate with learning and memory (Lubin et al., 2008; Miller & Sweatt, 2007), chronic exposure to drugs of abuse (Renthal & Nestler, 2008), and psychiatric illness (Grayson et al., 2005; Ptak & Petronis, 2008; Tsankova et al., 2007).”
EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “Importantly, aberrant bdnf gene expression has also been specifically implicated in the etiology of several of these mental illnesses, including schizophrenia, depression, and bipolar disorder (Weickert et al., 2003; Angelucci et al., 2005; Tsankova et al., 2007).”
Early Life Programming and Neurodevelopmental Disorders (2010, background): “Increasing evidence shows that numerous types of chromatin modifications, referred to as chromatin remodeling, are widespread in the brain and undergo dynamic regulation in both the developing and adult nervous system (6).”
The molecular neurobiology of depression (2008, neutral): “3 ) encompass covalent changes to DNA (for example, DNA methylation) and post-translational modifications of histone N-terminal tails (for example, acetylation and methylation), as well as non-transcriptional gene-silencing mechanisms (for example, microRNAs”