Rapid spontaneous accessibility of nucleosomal DNA

By Gu Li, M. Levitus, C. Bustamante, Jonathan Widom. Nature Structural &Molecular Biology, 2005

683 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/efe4c210f8c1919d534250e6a8a27bf71611a3ae

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Citations in the corpus

Histone Tails and the H3 αN Helix Regulate Nucleosome Mobility and Stability (2007, background): “6C), consistent with a role in constraining the “site exposure” mode of DNA unpeeling from the entry of the nucleosome (30).”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “Nucleosomal DNA is fully wrapped for ∼250 ms, and then transiently unwraps (10–50 ms), allowing proteins to access the DNA wrapped in nucleosomes (Li et al., 2005).”
A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. (2008, background): “…might be linked in some way to the underlying sequence, altered histone composition and/or modifications, or nucleosome fuzziness that changes from the 5Ј to the 3Ј ends of genes (Lieb and Clarke 2005; Yuan et al. 2005), and this might help RNA polymerase II traverse nucleosomes (Li et al. 2005).”
Stochastic mRNA Synthesis in Mammalian Cells (2006, background): “The structure of chromatin at the level of nucleosome stacking suggests that the ‘‘breathing’’ events that permit the entry of transcriptional regulators will be infrequent [36].”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “On the nucleosomal DNA, the farther is a site from the entry and exit points, the longer one has to wait to access it by the rarer spontaneous fluctuation of sufficiently large size [1968, 1969, 1970, 1971].”
ACF catalyses chromatosome movements in chromatin fibres (2008, background): “Since linker histones constrain the path of the linker DNA, they are expected to inhibit the dynamic detachment of DNA segments from the nucleosome (Li et al, 2005).”