β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

By D. Daniels, William I. Weis. Nature Structural &Molecular Biology, 2005

607 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2b78c65c172ab09116fb915a8ed7f0687c08c05e

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In Molecular Biology

1. K. Willert
2. K. Jones

Citations in the corpus

• Wnt/beta-catenin signaling in development and disease. (2006, unknown): “Tcf target sites are highly conserved between the four vertebrate Tcf/Lef proteins and Drosophila Tcf.”
• Wnt signaling: is the party in the nucleus? (2006, background): “…the C-terminal-binding protein (CtBP) corepressor, which influences epigenetic chromatin modifications through interactions with Polycomb corepressors and other factors (Chinnadurai 2002), and Groucho/ TLE1, which interacts directly with the LEF-1/TCF DNA-binding proteins (Daniels and Weis 2005).”
• The many faces and functions of β‐catenin (2012, unknown): “The binding of b -catenin physically displaces Groucho/TLE and converts TCFs into transcriptional activators, translating the Wnt signal into transcription of specific target genes (Cavallo et al , 1998; Daniels and Weis, 2005; Arce et al , 2009).”