ATP mediates rapid microglial response to local brain injury in vivo

By Dimitrios Davalos, J. Grutzendler, Guang Yang, Jiyun V. Kim, Yi Zuo, Steffen Jung, Dan R. Littman, Michael Loran Dustin, Wen-Biao Gan. Nature Neuroscience, 2005

3,753 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/224652d920e232f794db9357f359886cb5d52a28

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Citations in the corpus

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. (2008, background): “Microglial cells are the resident immune system phagocytic cells within the brain and spinal cord (Kim and de Vellis, 2005), and they also respond rapidly for neural protection or healing after injury (Davalos et al., 2005; Wu et al., 2007b).”
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “In the mature brain, microglia typically exist in a resting state characterized by ramified morphology, and monitor the brain environmen”
A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model (2013, neutral): “In response to tissue injury, microglia undergo a rapid transition from resting, ramified forms to amoeboid morphologies (Davalos et al., 2005).”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “Recent in vivo time-lapse imaging has revealed dynamic interactions between microglia and neurons in the brain following lesion or injury (Davalos et al., 2005; Nimmerjahn et al., 2005).”
Microglia: new roles for the synaptic stripper. (2013, neutral): “In the in vivo experiments by Davalos et al. (2005) it was evident that lowering extracellular ATP concentration by the ATP-hydrolyzing enzyme apyrase results in reduced process movements, whereas artificially created ATP gradients stimulate their motility.”
The Role of Microglia in the Healthy Brain (2011, background): “Factors known to have a pronounced, mostly stimulating but not necessarily “activating” influence over microglia dynamics include ATP and other nucleotides (Davalos et al., 2005; Dibaj et al., 2010a; Fontainhas et al., 2011).”
Macrophages: development and tissue specialization. (2015, background): “Tissue macrophages are nonmigratory cells that monitor their immediate, local environment, as strikingly visualized using intravital microscopy for microglia (126, 127).”
Inflammation as a central mechanism in Alzheimer's disease (2018, background): “Overall surveillance of the surrounding neuronal environment is accomplished via a large number of signaling mechanisms [99,102].”
Microglia promote learning-dependent synapse formation through BDNF (2013, background): “Because microglial processes are highly motile and located in close proximity to synaptic terminals (Davalos et al., 2005; Tremblay et al., 2010; Wake et al., 2009), our data raise the possibility that the release of BDNF from microglia may be regulated in a localized and/or activity-dependent fashi”
Microglial cell origin and phenotypes in health and disease (2011, background): “Following detection of signs of infection or tissue injury, microglia rapidly convert to an activated stat”