Microglia: new roles for the synaptic stripper.

By Helmut Kettenmann, F. Kirchhoff, Alexei Verkhratsky. Neuron, 2013

1,128 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/5e949577632a203d53a44cf2733882b6aefd14fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. M. Schwartz
6. M. Colonna
7. Alexei Verkhratsky
8. O. Butovsky

In Neurology

1. M. Pekny
2. M. Pekna
3. M. Sofroniew
4. E. Hol
5. Alexei Verkhratsky
6. M. Schwartz
7. M. Colonna
8. O. Butovsky

In Sensory Systems

1. Alexei Verkhratsky

Citations in the corpus

• Microglia development follows a stepwise program to regulate brain homeostasis (2016, background): “Perturbation of the microglial environment during development may alter the strict timing of developmental programs, leading to misplaced expression of gene pathways such as inflammation, disrupting neuronal development, and causing brain disorders at later stages in life (30).”
• Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “tracellular spaces and eliminate synaptic elements by phagocytosis (Brown and Neher 2014; Kettenmann et al. 2013; Schafer and Stevens 2010).”
• High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “The CNS myeloid compartment is the largest CNS-resident immune cell population and has been implicated in multiple aspects of CNS health and disease, including MS, AD, dementia, and Parkinson’s disease, as well as psychiatric diseases and behavioral disorders like schizophrenia, autism, and depressi”
• Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Importantly, microglia shape neuronal synapses by phagocytosing dendritic spines that are not receiving inputs from synaptic contacts (66, 67).”
• Astrocytes: a central element in neurological diseases (2016, background): “The synaptic assembly also includes a microglial cell process that frequently senses the synapse status [114, 229, 242].”