CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure.

By M. Fitch, J. Silver. Experimental Neurology, 2008

1,017 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/829fb2aa0bea6a32d38844f677b0b2194760ec4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Pekna
3. B. Barres
4. A. Tran
5. G. Ferraro
6. L. Mckerracher
7. P. Warren
8. A. Fournier

In Developmental Neuroscience

1. M. Pekny
2. M. Pekna
3. G. Ferraro
4. L. Mckerracher
5. A. Fournier
6. J. Silver
7. A. Tran
8. B. Barres

Citations in the corpus

• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Due to the high CSPG content within the glial scar, it is not surprising that axon regeneration and plasticity are hindered following SCI (FIGURE 8A) (5, 23, 35, 39, 98, 116, 123, 359, 380).”
• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Glial Scar and Extracellular Matrix Traumatic SCI triggers the formation of a glial scar tissue around the injury epicenter (266, 267).”
• Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury (2012, positive): “…(He and Koprivica, 2004; Buchli and Schwab, 2005), the deposition of inhibitory extracellular matrix molecules around injury sites (Fawcett, 2006; Fitch and Silver, 2008), and the lack of positive environmental stimuli such as 1264 Cell 150, 1264–1273, September 14, 2012 ª2012 Elsevier…”
• Rho signaling and axon regeneration. (2012, background): “Extracellular matrix deposited at a glial scar that forms after injury in the CNS is highly enriched in chondroitin sulfate proteoglycans (CSPGs), which are potent inhibitors of axon growth (Fitch & Silver, 2008; Rudge & Silver, 1990).”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “The negative, regeneration inhibiting side of prominent reactive astrogliosis and glial scarring has been appreciated for decades, and a host of molecules beyond IF proteins were implicated as potential targets (4, 29, 30, 35, 54, 72, 79, 221).”
• Genomic Analysis of Reactive Astrogliosis (2012, background): “For instance, reactive astrocytes can inhibit axon regeneration after CNS injury (McKeon et al., 1991; Bradbury et al., 2002; Fitch and Silver, 2008; Alilain et al., 2011) and can produce proinflammatory cytokines that exacerbate spinal cord injuries (Brambilla et al.”