Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

By G. Servant, O. Weiner, P. Herzmark, T. Balla, J. Sedat, H. Bourne. Science, 2000

894 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/20e17e7f53fd4c4cc7a4084da8fb1c0a9f516ab0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Kozo Kaibuchi
2. A. Ridley
3. M. Raftopoulou
4. A. Hall
5. T. Balla
6. N. Arimura
7. B. Vanhaesebroeck
8. C. Der

In Molecular Biology

1. T. Balla
2. Kozo Kaibuchi
3. A. Ridley
4. M. Raftopoulou
5. A. Hall
6. M. Thelen
7. N. Arimura
8. B. Vanhaesebroeck

Citations in the corpus

• Cell migration: Rho GTPases lead the way. (2004, background): “…bursts of PI(3,4,5)P3 induced in response to extracellular stimuli, and studies reported in Dictyostelium, neutrophils and fibroblasts reveal colocalization with centers of actin polymerization at the front of the migrating cell (Haugh et al., 2000; Parent et al., 1998; Servant et al., 2000).”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Since PtdIns(3,4,5)P3 has a pivotal role in amplifying polarization during chemotaxis both in phagocytic cells (1385, 1463) and lower organisms, such as Dictyostelium (976), there is a massive dysregulation of neutrophil polarization in Ship1 null mice (1140).”
• Guidance of primordial germ cell migration by the chemokine SDF-1. (2002, background): “…been shown pate in mouse PGC migration (Anderson et al., 1999; to polarize cells such as neutrophils that respond to Bendel-Stenzel et al., 2000) should also be examined in chemoattractants by polarizing the distribution of PIP3 the zebrafish system. and directed migration (Servant et al., 2000).”
• PI3K signalling: the path to discovery and understanding (2012, background): “, leading to the discovery that PI3K signalling becomes highly polarized towards the leading edge in motile cell”
• Dancing to the tune of chemokines (2001, background): “Differentiated HL-60 cells that were transfected with a green fluorescent protein (GFP)-tagged PH-domain of PKB (PHAKT-GFP) showed an asymmetric translocation of the construct to the plasma membrane at the leading edg”
• Neuronal polarity: from extracellular signals to intracellular mechanisms (2007, background): “PI3K and PtdIns(3,4,5)P 3 exhibit a polarized activation and distribution during chemotaxis in neutrophil”
• Rho GTPases and cell migration. (2001, background): “Interestingly, myosins might also act upstream of Rac: a novel myosin in Dictyostelium has an exchange factor domain for Rac1, and can promote cell protrusion (Geissler et al., 2000).”