Dancing to the tune of chemokines

By M. Thelen. Nature Immunology, 2001

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The role of CXC chemokines and their receptors in cancer. (2008, background): “Most, if not all chemokines activate leukocytes through binding to G protein-coupled seven transmembrane receptors (GPCR) designated CXCR or CCR [8,9].”
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “The G proteins associatewith the carboxyl terminus of the receptor and signal-induced conformational changes activates G protein-mediated signalling [60].”
Adhesion mechanisms regulating the migration of monocytes (2004, background): “Signalling occurs through different types of second messenger, which depend on the type of chemokine and its receptor”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “However, the signal transduction pathway involves stimulated arrestin recruitment and chemokine-enhanced coupling to the internalization machinery, for which activation of heterotrimeric G proteins by GPCRs is dispensable (Thelen, 2001) and the physiologic role of which remains unknown.”
Chemokines and disease (2001, background): “Granule exocytosis, gene transcription, mitogenic effects and apoptosis are also affected by chemokines (see the review by Thele”