Cell migration: Rho GTPases lead the way.

By M. Raftopoulou, A. Hall. Developmental Biology, 2004

1,504 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96f75305e7ef9f55406cfb4091f866fead91cf00

How researchers see this paper

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In Cell Biology

1. Valerie M. Weaver
2. S. Mayor
3. M. Maeda
4. R. Pagano
5. Sanjay Kumar
6. M. Humphries
7. G. Gundersen
8. M. Wheelock

In Molecular Biology

1. C. Heldin
2. A. Moustakas
3. K. Rossman
4. C. Der
5. S. Mayor
6. M. Maeda
7. R. Pagano
8. Valerie M. Weaver

Citations in the corpus

• Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase (2005, background): “The molecular mechanisms that lead to focal adhesion assembly have been well characterized, with particular emphasis on the role of Rho family GTPases and integrin engagemen”
• Signal transduction in cancer. (2015, background): “the actomyosin contractile machinery, the kinase LIMK, and cofilins (Raftopoulou and Hall 2004);”
• Cadherin switching (2008, background): “GTPase-activating proteins (GAPs) activate GTPase activity to inactivate the protein, and guanine nucleotide dissociation inhibitors (GDIs) sequester the GTPase in its inactive form, which provides further negative regulation (Raftopoulou and Hall, 2004).”
• Pathways of clathrin-independent endocytosis (2007, background): “However, this terminology is not meant to imply that a given GTPase is directly involved only in a particular internalization mechanism — these pathways have been primarily defined by mutants of these GTPases, which are likely to affect many cellular processe”
• Non-Smad TGF-β signals (2005, background): “Since Limk1 is a well-studied kinase that signals downstream of Rho GTPases and regulates reorganization of the actin cytoskeleton (Raftopoulou and Hall, 2004), this observation may be relevant to the mechanism by which BMPs regulate the actin cytoskeleton during neuronal dendrite morphogenesis…”
• Integrin signalling during tumour progression (2004, background): “The Rho GTPases mediate many of the integrin-dependent modifications of the actin cytoskeleton that are necessary for cell migratio”
• Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “The spatiotemporal regulation of these physical structures is driven by a variety of signaling molecules and their downstream effectors; the most prominent of these are the Rho family GTPases (see Raftopoulou & Hall 2004 for a review).”
• Synergistic control of cell adhesion by integrins and syndecans (2007, background): “The Rho family of GTPases is central to cytoskeletal organization; members of this family cycle between active (GTP-bound) and inactive (GDP-bound) forms owing to their intrinsic GTPase activit”
• Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “Rho activation has been linked in a wide variety of culture systems to actomyosin contractility, formation of stress fiber bundles, and reinforcement and maturation of focal adhesions [128].”
• GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors (2005, background): “Rho-family proteins are regulators of the actin cytoskeleton, cell-cycle progression and gene transcription, and have been implicated in cellular processes such as adhesion and migration, PHAGOCYTOSIS , CYTOKINESIS , neurite extension and retraction, cellular morphogenesis and polarization, growth”