Rho GTPases and cell migration.

By A. Ridley. Journal of Cell Science, 2001

1,231 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7e890e362bb134067bdd7a50814c5c2b017df491

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Citations in the corpus

Modes of neuronal migration in the developing cerebral cortex (2002, background): “Recent evidence indicates that, whereas the extension of the leading process is mediated by the polymerization and reorganization of actin microfilaments, which is controlled by GTPases of the RHO famil”
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. (2003, background): “In particular, Rho GTPases (ARHC) and mitogen-activated protein kinases are members of Ras signal transduction pathways known to play a role in tumorigenesis and cell migration (17, 18).”
ROCKs: multifunctional kinases in cell behaviour (2003, background): “The driving force for cell movement is normally provided by dynamic reorganization of the actin cytoskeleton, which is regulated by the Rho-family GTPases: the activity of Cdc42 is required for cell polarity (at least in yeast, T cells, MACROPHAGES and ASTROCYTES ); Rac controls the formation of ”
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly (2004, background): “Because Rac is a key regulator of migration and active Rac localizes at the leading edge of motile cell”
Conserved microtubule–actin interactions in cell movement and morphogenesis (2003, background): “Two key factors are known to function downstream of RhoA: Rho kinase, which promotes contractility by increasing phosphorylation of the regulatory light chain of myosin-2 (ref”
Rho GTPases in cell biology (2002, background): “This in itself is not sufficient, however, and cell contractility is required to allow the body and rear of the cell to follow the extending fron”
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. (2003, unknown): “to promote formation of actin polymers (Ridley, 2001; Tapon and Hall, 1997).”
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis (2003, background): “The Rho family of small GTPases, of which the best studied members are Cdc42, Rac1 and Rho”
Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “Dominant-negative RAC1 inhibits lamellipodium extension, membrane ruffling and migration in multiple cell types, including macrophages, T cells, epithelial cells and fibroblast”