PI3K signalling: the path to discovery and understanding

By B. Vanhaesebroeck, L. Stephens, P. Hawkins. Nature reviews. Molecular cell biology, 2012

942 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/522eb12d857619a61d2de5d77a45d43f4be4085b

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In Molecular Biology

1. Ping Wee
2. Zhixiang Wang
3. T. Balla
4. Fazlul H. Sarkar
5. Lewis C. Cantley
6. Asfar S. Azmi
7. D. Auld
8. R. Roskoski

Citations in the corpus

• The ErbB/HER family of protein-tyrosine kinases and cancer. (2014, background): “Akt also catalyzes the phosphorylation and nhibition of Bcl2-associated death promoter (BAD); unphosphoylated BAD is pro-apoptotic [85].”
• PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma (2014, neutral): “Subtypes of indolent non-Hodgkin’s lymphoma included follicular lymphoma (72 patients), small lymphocytic lymphoma (28), marginal-zone lymphoma (15), and lymphoplasmacytic lymphoma with or without Waldenström’s macroglobulinemia (10).”
• A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation (2013, background): “Dysregulation of these pathways can lead to cancer and other diseases [1,2,3,4,5,6].”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Several excellent reviews have summarized various aspects of this topic in greater details in recent years (75, 221, 467, 814, 996, 1609, 1612, 1613, 1640, 1727, 1785).”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Primarily, PTEN works by keeping PI3K-AKT pathway (found constitutively activated in cancers) in check and regulates cell cycle progression [96].”
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Here, we will review the activation mechanisms by which the EGFR activates the ERK MAPK, AKT-PI3K, and PLC-γ1-PKC pathways, focusing on the molecular interactions between each protein in the pathways (Figure 1).”