MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

By M. Fabbri, A. Paone, Federica Calore, R. Galli, E. Gaudio, R. Santhanam, F. Lovat, P. Fadda, C. Mao, G. Nuovo and 9 more. Proceedings of the National Academy of Sciences of the United States of America, 2012

1,498 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/20c645ee15fd2c99d8706d6b846b0cbe6c0b34fa

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Citations in the corpus

The biology, function, and biomedical applications of exosomes (2020, neutral): “Exosomal miR-21 andmiR-29a from cancer cells trigger human TLR8 and mouse TLR7-mediated NF-kB (nuclear factor-kB) activation inmacrophages and the production of IL-6 and TNF-a to promote melanoma lung metastasis and lung cancer in mice (93).”
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. (2014, background): “In cancer, Cell 159, 499–513, October 23, 2014 ª2014 Elsevier Inc. 499 exosomes secreted by tumor cells can increase metastasis through interaction with cells of the microenvironment (Fabbri et al., 2012; Peinado et al., 2012).”
Exosomes in cancer: small particle, big player (2015, background): “suggest that miRNAs in tumor-secreted exosomes can directly bind toll-like receptor (TLR) in immune cells to promote tumor metastasis [46].”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “Extracellular miRNAs have also been reported to bind to Toll-like receptors (137), activate downstream signaling events, and eventually lead to biological responses, such as tumor growth and metastasis (138), and neurodegeneration (139).”
Exosomes and their roles in immune regulation and cancer. (2015, background): “In fact, oncogene miR-21 and -29a secreted from lung cancer cell-derived exosomes were shown to bind TLRs to murine (TLR7) and human (TLR8), leading to TLR-mediated NF- B activation and secretion of pro-metastatic inflammatory cytokines TNF- and IL-6 [134].”
Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “[44] describe significantly lower number of lung metastases.”
Quantitative and stoichiometric analysis of the microRNA content of exosomes (2014, background): “Such activities include the elicitation of cellular responses through binding of Toll-like receptors (42, 43) as well as potential effects of small RNAs on DNA transcription and/or epigenetic states (44).”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “In turn, these cytokines were shown to induce the formation of a pulmonary microenvironment supportive of lung metastatic burden (Fabbri et al., 2012).”
Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “miRNAs carried by EVs can also activate Tolllike receptor (TLR) 8 signaling which induces cytokine secretion, by presumably mimicking viral RNA [79].”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “For example, CD9 and CD63 are tetraspanin proteins found enriched in EVs which, when tagged with GFP, can be used to show uptake and processing of vesicles in cells (10,47,48).”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “Exosomal miR-21 and miR-29a, in addition to the classic role of targeting mRNA, were ﬁrst discovered to have the capacity to act as ligands that bind to toll-like receptors (TLRs) and activate immune cells [73].”
Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study (2015, background): “• Differentially regulated in a number of cancer types including colorectal non-small cell lung cancer and prostate cancer miR-21 • Decreased in type 2 Diabetes in the Bruneck cohort [35, 43, 44, 49] • Increased in patients with CVD compared to aged matched non-CVD individuals while also correlating”
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “miR-21 and miR-29a can bind to TLR 7 and TLR 8 as agonists, leading to NF-κB signaling activation and secretion of IL-6 and TNF-α, which locally promote cancer cell growth and metastasis when treating cancer, and may cause systemic immune toxicity [74].”