Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
By Jian Zhang, Sha Li, Lu Li, Meng Li, Chongye Guo, Jun Yao, Shuangli Mi. Genomics, Proteomics & Bioinformatics, 2015
1,969 citations recorded by the source corpus.
Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal miRNAs, since the miRNA profiles of exosomes may differ from those of the parent cells. Exosomal miRNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal miRNAs, and briefly describe how exosomes and their miRNAs function in recipient cells. Finally, we will discuss the potential applications of these miRNA-containing vesicles in clinical settings.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7582f7ee49601271ab92c2e987bcd2c7115829ac
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Citations in the corpus
- microRNA as Biomarkers and Diagnostics (2016, background): “…membrane-derived vesicles that participate in cell-to-cell communication and protein and RNA delivery (Lin et al., 2015). miRNAs have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate physiology of the recipient cells (Zhang et al., 2015).”
- Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. (2017, positive): “Our ATM exosomal preparations were made using published techniques (Fong et al., 2015; Zhang et al., 2015b), and these Cell 171, 1–13, October 5, 2017 9 Please cite this article in press as: Ying et al., Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin…”
- Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “With knockdown of Rab27 or its effectors SYTL4 and EXPH5 inhibiting secretion of exosomes in HeLa cells [20, 21].”