In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
By Yunching Chen, Dong-Yu Gao, Leaf Huang. Advanced Drug Delivery Reviews, 2014
614 citations recorded by the source corpus.
MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in cancer cells, play an important role in modulating gene expressions, thereby regulating downstream signaling pathways and affecting cancer formation and progression. Oncogenes or tumor suppressor genes regulated by miRNAs mediate cell cycle progression, metabolism, cell death, angiogenesis, metastasis and immunosuppression in cancer. Recently, miRNAs have emerged as therapeutic targets or tools and biomarkers for diagnosis and therapy monitoring in cancer. Since miRNAs can regulate multiple cancer-related genes simultaneously, using miRNAs as a therapeutic approach plays an important role in cancer therapy. However, one of the major challenges of miRNA-based cancer therapy is to achieve specific, efficient and safe systemic delivery of therapeutic miRNAs In vivo. This review discusses the key challenges to the development of the carriers for miRNA-based therapy and explores current strategies to systemically deliver miRNAs to cancer without induction of toxicity.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/14a86867932d2d6ce898ee703326c6e79ad0fa09
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In Cancer Research
In Molecular Biology
Citations in the corpus
- An overview of microRNAs (2015, background): “As miRNAs become causally linked to increasing numbers of human diseases there are expanding efforts to develop therapeutics that directly target the miRNA[234-236].”