RNA Silencing Genes Control de Novo DNA Methylation

By S. Chan, Daniel Zilberman, Zhixin Xie, Lisa K. Johansen, James C. Carrington, Steven E. Jacobsen. Science, 2004

597 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/1fe0d797591fee60cf7466c6e69fae0e7403b967

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Citations in the corpus

Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs. (2005, background): “Although DCL3 appears to be the primary R CL producing RDR2-dependent siRNAs, which direct ranscriptional gene silencing and heterochromatin odification [17, 5], the absence of phenotypes in the cl3 mutant, even after several generations, indicated hat both DCL2 and DCL4 are functionally compensaory”
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. (2006, background): “The candidate siRNAs were mostly 24mers, the size of siRNAs associated with PolIV, heterochromatin formation, and DNA methylation (Chan et al. 2004; Xie et al. 2004; Herr et al. 2005; Kanno et al. 2005; Onodera et al. 2005; Pontier et al. 2005).”
Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis (2005, unknown): “retroelements and transposons, 5S ribosomal RNA genes, endogenous direct and inverted repeats, and transgenes containing direct repeats (Chan et al., 2004; Xie et al., 2004; Zilberman et al., 2004; Herr et al., 2005; Onodera et al., 2005).”
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome (2013, unknown): “However, in RdDM mutants, the transgene fails to be methylated, causing ectopic expression that leads to a late-flowering phenotype (Ausin et al., 2009; Chan et al., 2004; Greenberg et al., 2011).”
Micro RNAs and Short‐interfering RNAs in Plants (2007, background): “With the exception of a few repetitive element-associated 24-nt siRNAs in heterochromatin formation and silencing of transposons and repetitive elements (Zilberman et al. 2003; Chan et al. 2004; Xie et al. 2004), 21-nt tasiRNAs in plant development (Fahlgren et al.”
Epigenetic silencing of transposable elements: a trade-off between reduced transposition and deleterious effects on neighboring gene expression. (2009, background): “Using sRNA targeting as a proxy for methylation Both de novo DNA methylation and restoration of methylation patterns are dependent upon sRNA, which targets homologous sequences for epigenetic modification (Chan et al. 2004; Teixeira et al. 2009).”
Specialization and evolution of endogenous small RNA pathways (2007, background): “thaliana accumulates endogenous 24-nucleotide siRNAs from transposons, retroelements and other features through an RDR2–DCL3-dependent mechanis”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “Endogenous or transgene-derived siRNAs that correspond to promoter sequences guide DNA methylation in homologous promoter sequences, which is assumed to be, at least in part, responsible for TGS (Mette et al. 2000; Matzke et al. 2001; Chan et al. 2004).”
RNAi-mediated pathways in the nucleus (2005, unknown): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=828658">FWA , leading to its silencin”