Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs.

By Virginie Gasciolli, A. Mallory, David P. Bartel, H. Vaucheret. Current Biology, 2005

641 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/c52d1d4334a252296d405b1e0b841fe84ae8f9cc

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Citations in the corpus

Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3 (2006, background): “…ETTIN/ARF3 and ARF4, are targets of trans-acting siRNAs (tasiRNAs) (Allen et al., 2005; Williams et al., 2005). ta-siRNAs are produced by a pathway involving SGS3, RDR6 and DCL4 from transcripts that are cleaved by a miRNA (Dunoyer et al., 2005; Gasciolli et al., 2005; Yoshikawa et al., 2005).”
Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA affects developmental timing and patterning in Arabidopsis. (2006, background): “Nontargeted ARF3mut Triggers Accelerated Phase Change Given that general ta-siRNA-defective mutants (rdr6-15 and dcl4-2) and zip-1 exhibit accelerated vegetative phase-change phenotypes [2, 4, 6, 9], and that ZIPdependent TAS3 ta-siRNAs are known to target ARF3 and ARF4 [1], we hypothesized that the”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “…is that after miRNAguided cleavage, one of the two cleavage products is transformed into dsRNA by RDR6, and sequentially processed into 21-nt ta-siRNAs by DCL4 (Peragine et al. 2004; Vazquez et al. 2004b; Allen et al. 2005; Gasciolli et al. 2005; Xie et al. 2005b; Yoshikawa et al. 2005).”
Small RNAs and Their Roles in Plant Development (2009, background): “…2002, Rajagopalan et al. 2006, Reinhart et al. 2002), which appears to prefer long dsRNA substrates such as hairpin RNAs, viral RNAs, and dsRNAs generated by RDR6 at transgene or ta-siRNA loci (Deleris et al. 2006, Fusaro et al. 2006, Gasciolli et al. 2005, Xie et al. 2005b, Yoshikawa et al. 2005).”
MicroRNAS and their regulatory roles in plants. (2006, background): “None of the other three Dicerlike enzymes in Arabidopsis is required for miRNA biogenesis (41, 142), suggesting that DCL1 also makes the second set of cuts.”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “There is, however, some overlap and compensatory processing by the four Arabidopsis DCLs in single dcl mutants (Gasciolli et al., 2005).”
High-Throughput Sequencing of Arabidopsis microRNAs: Evidence for Frequent Birth and Death of MIRNA Genes (2007, background): “Dual targeting of the CHX18 (At5g41610) transcript may lead to secondary, 21 nt siRNAs that arise through the RDR6/DCL4-dependent pathway ([29,34–39]; data not shown).”
A two-hit trigger for siRNA biogenesis in plants. (2006, positive): “We note that this model postulates that the triggers for tasiRNA biogenesis and siRNA-mediated virus resistance are mechanistically similar—a postulate supported by the fact that a single Dicerlike protein, DCL4, is primarily responsible for both processes in wild-type Arabidopsis (Gasciolli et al.,”
The timing of developmental transitions in plants. (2006, background): “A similar phase-change defect has been found in dicerlike4 (dcl4) mutants (Gasciolli et al., 2005; Xie et al., 2005; Yoshikawa et al., 2005).”
Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation. (2008, background): “Although an RDR6/DCL4 processing center has not been identified, RNA-processing centers with roles in silencing, such as P bodies (Liu et al., 2005), have been identified.”
Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis (2005, positive): “DCL2 is involved in the production of some viral siRNAs (Xie et al., 2004) and may substitute for DCL3 or DCL4 when they are absent (Gasciolli et al., 2005).”
Micro RNAs and Short‐interfering RNAs in Plants (2007, background): “…and RDR2 but not SGS3 and RDR6, but resembles the miRNA pathway, which requires AGO1, DCL1, HEN1, and HYL1, because tasiRNA primary transcripts are targeted by miRNAs, miR173 and miR390 in plants (Allen et al. 2005; Xie et al. 2005; Gasciolli et al. 2005; Yoshikawa et al. 2005; Axtell et al. 2006).”
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. (2006, background): “2005; Gasciolli et al. 2005; Yoshikawa et al. 2005; Axtell et al. 2006), we searched TAS4 for miRNA complementary sites upstream of and downstream from the region that generated small RNAs.”
Evolution and Functional Diversification of MIRNA Genes (2011, background): “Accumulation of these miRNAs is dependent on DCL1, and not DCL2, which generates 22-nucleotide siRNAs from long double-stranded RNA (Park et al., 2002; Gasciolli et al., 2005; Xie et al., 2005; Bouché et al., 2006; Deleris et al., 2006; Lu et al., 2006; Montgomery et al., 2008b; Cuperus et al., 2010”