Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

By Yoshinori Takahashi, D. Coppola, Norimasa Matsushita, H. Cualing, Mei Sun, Yuya Sato, Chengyu Liang, Jae U. Jung, Jin Q. Cheng, James J. Mul and 2 more. Nature Cell Biology, 2007

975 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/bb98c416fee457e42e9f7ec1a091dc52675dad24

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Citations in the corpus

Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “Bif1 (also present in Golgi complex) is mainly involved in endosome formation, also binds to positive regulator complex of autophagy, UVRAG and beclin-1, and promotes autophagy (Takahashi et al., 2007, 2008).”
Autophagy in malignant transformation and cancer progression (2015, positive): “Along similar lines, AMBRA1 is mutated in a subset of endometrial, colorectal and urinary tract neoplasms (Cianfanelli et al , 2015), the gene coding for the BECN1 activator UV radiation resistance associated (UVRAG) is monoallelically mutated in a high proportion of gastric and colonic tumors (Lian”
A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, background): “Endophilin B1 has been implicated in the binding of Bax (Pierrat et al, 2001), beclin (Takahashi et al, 2007) and in the process mitochondrial fission (Karbowski et al, 2004).”
The regulation of autophagy – unanswered questions (2011, background): “, 2008) and Bax-interacting factor 1 (Bif1) (Takahashi et al., 2007) positively regulate autophagy, whereas the RUN domain and cysteine-rich domain containing beclin-1-interacting protein (rubicon) (Matsunaga et al.”
An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Two positive regulators of the PtdIns3K complex are AMBRA1 (which directly binds BECN1) and SH3GLB1/Bif-1 (which interacts with BECN1 through UVRAG, and may be involved in generating membrane curvature) (29, 133, 135).”
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking (2008, background): “Results UVRAG interacts with C-Vps in vivo Full-length UVRAG is predicted to contain an amino-terminal proline-rich (PR) region (residues 1–41) that mediates Bif-1 interaction, followed by a putative Ca 2+ -dependent phospholipid binding C2 domain (residues 42–147), a central Beclin1-bind”
The Roles of Autophagy in Cancer (2018, background): “The depletion of UVRAG and decrease of Bif-1 impaired autophagosome formation and autophagy, resulting in increased cancer-cell proliferation in colon, gastric, breast, and prostate cancers [45,48,60,61].”