Autophagy-Dependent Ferroptosis: Machinery and Regulation

By Jiao Liu, Feimei Kuang, Guido Kroemer, D. Klionsky, R. Kang, D. Tang. Cell Chemical Biology, 2020

719 citations recorded by the source corpus.

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular process capable of degrading various biological molecules (e.g., protein, glycogen, lipids, DNA, and RNA) and organelles (e.g., mitochondria, endoplasmic reticulum, ribosomes, lysosomes, and micronuclei) via the lysosomal pathway. Ferroptosis is a type of oxidative stress-dependent regulated cell death associated with iron accumulation and lipid peroxidation. The recently discovered role of autophagy, especially selective types of autophagy (e.g., ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy), in driving cells towards ferroptotic death motivated us to explore the functional interactions between metabolism, immunity, and cell death. Here, we describe types of selective autophagy and discuss the regulatory mechanisms and signaling pathways of autophagy-dependent ferroptosis. We also summarize chemical modulators that are currently available for triggering or blocking autophagy-dependent ferroptosis and that may be developed for therapeutic interventions in human diseases.

Subfields: Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/6310b61383693a214bf287b4b790de8602d5121a

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Citations in the corpus

Copper metabolism in cell death and autophagy (2023, background): “For example, recent studies have highlighted that ferroptosis is a type of autophagy-dependent cell death due to autophagy-mediated degradation of antiferroptotic factors [178,179], such as ferritin [180,181], lipid droplets [182], GPX4 [152,183–185], or CDH2 (cadherin 2) [186].”
ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis (2023, background): “Oxidative stress and lipid peroxidation products (such as MDA, ROS, and 4-HNE) are powerful inducers of autophagy, while excessive autophagy promotes ferroptosis (Liu et al. 2020; Zhou et al. 2020).”