Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia.

By R. Bruick. Proceedings of the National Academy of Sciences of the United States of America, 2000

783 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1e33513eac28dcdba5a5e0e62a63d30916896245

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Citations in the corpus

Hypoxia-Inducible Factor-1 (HIF-1) (2006, positive): “Moreover, hypoxia depressed the antiapoptotic protein Bcl-2 (Carmeliet et al., 1998), whereas the proapoptotic protein Bcl-2/adenovirus EIB 19-kDa interacting protein 3 (BNip3) and its homolog Nip3-like protein X (NIX) were up-regulated in a HIF-dependent manner (Bruick, 2000).”
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation (2003, neutral): “Furthermore, the hypoxia-inducible proapoptotic gene bNIP-3 is also only active in acidic environments (9, 96).”
ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, positive): “Regulation of NIX by hypoxia in tumor cell lines is also reported.(18,19,21) In U2OS osteosarcoma cells, NIX is regulated transcriptionally and post-transcriptionally by hypoxia and p53.”
The role of hypoxia-inducible factors in tumorigenesis (2008, background): “It has been reported that HIF-1 can directly induce the expression of the proapoptotic genes BNIP3 and NIX in a variety of human cancer cell lines, macrophages, and endothelial cells.(98,99)”
Targeting HIF-1 for cancer therapy (2003, background): “cgi?l=664"> BNIP3 , which encodes a pro-apoptotic BCL2 family membe”
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. (2001, background): “However, experimental evidence suggests that HIF-1-regulated gene products (e.g., NIP3) may also mediate hypoxia-induced apoptosis under certain conditions (Carmeliet et al. 1998; Bruick 2000).”
Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, background): “One particular HIF-induced gene that seems not to be repressed by the activity of FIH is the pro-apoptotic bnip3 , a member of the BH3-only protein family of cell death factor”
HIF‐1α induces cell cycle arrest by functionally counteracting Myc (2004, background): “promote apoptosis (Carmeliet et al, 1998; Bruick, 2000).”
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. (2007, positive): “…generated from hyp-oxia-response elements (HREs) in the EPO, ALDA, Vegf, CP, ID2, BNIP3, and NOXA genes (Semenza et al., 1996; Shima et al., 1996; Bruick, 2000; Mukhopadhyay et al., 2000; Kim et al., 2004; Lofstedt et al., 2004) and consisted of the core HIF-1-binding site 5 0 -RCGTG-3 0…”
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells (2004, methodology): “, Eugene, OR, USA) using flow cytometry as described previously.(41) Treated cells were collected with trypsinization, washed twice with PBS, and stained with 150 nM TMRE in PBS in the dark at 371C for 30 min.”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “Their expression levels are regulated by hypoxiainducible factor-1 (HIF-1), and HIF-1 binding to a site on the Bnip3 promoter is enhanced (Bruick , 2000 ; Guo et al. , 2001 ) in cells during hypoxia.”
Cell Death Signaling. (2015, background): “…Type of regulation Signaling pathway Output References BMF TGFb Sequestration DLC2 Antiapoptotic Puthalakath 2001 Transcription HIFa Proapoptotic Bruick 2000; Guo 2001 BNIP3 Hypoxia Transcription E2F1 Proapoptotic Yurkova 2008 Transcription inhibition NF-kB Antiapoptotic Shaw 2006,…”