Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

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LC3 conjugation system in mammalian autophagy (2004, background): “Treatment of glioma cell cultures with TMZ (5-1000 M) was found to inhibit cell viability and increase the number of LC3-positive autophagic vacuoles, showing that TMZ stimulates autophagy in glioma cells (Kanzawa et al., 2004).”
Autophagy and autophagy-related proteins in cancer (2020, background): “lignant glioma cells [260, 261], Temozolomide (TMZ) in malignant glioma cells [262], γ-irradiation in breast cancer, prostate cancer, colon cancer and malignant glioma [263–265], resveratrol in ovarian cancer [266], TNFα in breast cancer cells [267], IFNγ in Hepatocellular carcinoma (HCC) [268], ima”
Inhibition of Macroautophagy Triggers Apoptosis (2005, background): “For example, type 2 cell death affects degenerating neurons in some pathologies (17, 39), participates in retinal degeneration (24), seals the fate of Salmonella-infected macrophages (26), and sometimes mediates chemotherapy-induced tumor killing (30, 31, 55).”
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease (2005, background): “stress, exposure to toxins (Kanzawa et al., 2004), or dysfunc-”
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. (2005, background): “Elimination of extracellular factors on which cells depend to maintain anapleurotictherapy drugs (Daido et al., 2004; Kanzawa et al., 2004; Paglin et al., 2001; Talloczy et al., 2002).”