Brain structural abnormalities in young children with autism spectrum disorder

By B. Sparks, S. Friedman, D. Shaw, E. Aylward, D. Echelard, A. Artru, K. Maravilla, Jay N. Giedd, Jeff Munson, Geraldine Dawson and 1 more. Neurology, 2002

947 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/1de49d82baea7e89919ed980d124f2ca448c8074

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Citations in the corpus

Autism and Abnormal Development of Brain Connectivity (2004, background): “MRI morphometry in young children with autism reveals excessive volume of cerebrum or cerebral white matter (Courchesne et al., 2001; Sparks et al., 2002; Herbert et al., 2003) or increased total brain volume (Piven et al., 1995; Aylward et al., Figure 1 .”
Early Social Interaction Project for Children With Autism Spectrum Disorders Beginning in the Second Year of Life (2006, result): “The findings on developmental regression are particularly interesting in light of recent brain research studies suggesting that an overgrowth of the brains of children with ASD occurs over the first few years of life (Courchesne et al., 2001; Lainhart et al., 1997; Piven, Arndt, Bailey, & Andreasen,”
Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain (2008, methodology): “problem of inter-rater variability which limits the reliability of manual labeling (Sparks et al., 2002).”
Accelerated maturation of white matter in young children with autism: A high b value DWI study (2007, background): “Studies reported smaller volumes of the cerebellar vermis (Akshoomoff et al., 2004; Carper and Courchesne, 2005; Carper et al., 2002; Courchesne et al., 2001), as well as abnormalities in the amygdalae and hippocampi in children with autism, ages 3– 4 years (Sparks et al., 2002).”
The Amygdala Is Enlarged in Children But Not Adolescents with Autism; the Hippocampus Is Enlarged at All Ages (2004, background): “, 1999), whereas others have reported increased volumes (Sparks et al., 2002), and still others have found no significant differences (Piven et al.”
Evidence of brain overgrowth in the first year of life in autism. (2003, background): “Another study reported that brain size in 4-year-old children with autism exceeded the healthy average.(11) Excessive brain size was primarily due to increased white matter volumes in the cerebellum and cerebrum(9) and increased gray matter volume in the cerebrum, within which frontal lobes were mos”
Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. (2005, background): “Recent studies have discovered that although infants who will eventually develop autism are born with normal to slightly smaller than normal brain sizes, soon thereafter the brain grows at an excessive rate, leaving the autistic toddler with an enlarged brain volume [19,20 ,21].”
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. (2010, background): “…et al., 1999; Dietzmann and von Bossanyi, 1994; Ferrer and Galofre, 1987; Fiala et al., 2002; Garey et al., 1998; Huttenlocher and Dabholkar, 1997; Irwin et al., 2000, 2001; Jacobs et al., 1997, 2001; Michel and Garey, 1984; Multani et al., 1994; Suetsugu and Mehraein, 1980; Swann et al., 2000).”
Mapping early brain development in autism. (2007, neutral): “By 2–4 years of age, some regions and structures display over-growth while others do not (Carper and Courchesne, 2005; Carper et al., 2002; Sparks et al., 2002).”