Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection.

By Eric Courchesne, K. Pierce. Current Opinion in Neurobiology, 2005

976 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/7c7c4e41f9dfd00ae4ed7b211e7ea1fbc3f99bfd

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Citations in the corpus

Autism spectrum disorders: developmental disconnection syndromes (2007, methodology): “Here, we provide a synthesis of data published mostly in the past two years that support the emerging hypothesis that the autisms result from disconnection of brain regions that are highly evolved in humans and that are involved in higher-order associations [10,11] (in other words, that ASDs form a ”
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception (2006, background): “A related consequence of this uncertainty is that predictions derived from the UCH are contradictory at least for frontal lobes (underconnectivity in Just et al., 2005; over-synchrony in Courchesne & Pierce, 2005).”
Salience Network–Based Classification and Prediction of Symptom Severity in Children With Autism (2013, positive): “The underconnectivity theory of autism posits that the disorder results from reduced functional connectivity between frontal and posterior cortical regions.(6,65,66) It is not yet clear how connectivity measures can be affected by methodologic choices.”
The rises and falls of disconnection syndromes. (2005, background): “…dysfunctions range from classical disconnection syndromes such as the conduction aphasia of pure subcortical lesions (Naeser et al., 1982) to the combination of frontofrontal hyperconnectivity with frontal disconnection from other brain regions in autism (Courchesne and Pierce, 2005).”
Evaluation of ICA-AROMA and alternative strategies for motion artifact removal in resting state fMRI (2015, background): “…directly interfere with current hypotheses about local and long-distance functional connectivity in the context of neurodevelopment and Autism Spectrum Disorders (ASD; Courchesne and Pierce (2005), Fair et al. (2007, 2008, 2009), Kelly et al. (2009), Dosenbach et al. (2010), Power et al. (2010)).”
Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009, neutral): “This may result in further altered long-range connectivity [80, 81], vital for communication between neocortical modules and hemispheres [74, 82 – 85].”
Mapping early brain development in autism. (2007, positive): “…rise to a new hypothesis: early brain development in autism is characterized by two phases of brain growth pathology (Courch-esne et al., 2001, 2003; Courchesne and Pierce, 2005a): early brain overgrowth at the beginning of life and slowing or arrest of growth during early childhood (Figure 1).”