Evidence of brain overgrowth in the first year of life in autism.

By Eric Courchesne, Ruth A. Carper, N. Akshoomoff. Journal of the American Medical Association (JAMA), 2003

1,068 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Pediatrics, Perinatology and Child Health, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/25be74099f92f476d6d2725cd45194f88362b7ce

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In Cognitive Neuroscience

In Pediatrics, Perinatology and Child Health

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Citations in the corpus

Autism and Abnormal Development of Brain Connectivity (2004, background): “Retrospective analyses of head circumference measurements suggest that much of the overgrowth occurs postnatally within the first 6 –14 months (Courchesne et al., 2003), coinciding with what is normally a period of exuberant synaptogenesis, dendritic arborization, and ongoing myelination.”
Localization of white matter volume increase in autism and developmental language disorder (2004, background): “Retrospective head circumference studies of autistic children demonstrate increases in percentile as great as two standard deviations between birth and two years of age.(7,8) Indeed, by the time autistic children are 2 to 4 years old, 90% have aboveaverage brain volumes and 37% are frankly macroceph”
The developing brain and neural plasticity: Implications for normality, psychopathology, and resilience. (2015, background): “…volume found in children with Autism may potentially reflect abnormalities in any number of microstructural features, including excessive numbers of neurons and/or glial cells, excessive dendridtic arborization, and/or atypically large numbers of axonal connections (Courchesne et al., 2003).”
Why Are Autism Spectrum Conditions More Prevalent in Males? (2011, neutral): “Total brain volume 3 [20,141–143]”
Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. (2005, background): “Recent studies have discovered that although infants who will eventually develop autism are born with normal to slightly smaller than normal brain sizes, soon thereafter the brain grows at an excessive rate, leaving the autistic toddler with an enlarged brain volume [19,20 ,21].”
A synaptic trek to autism. (2009, background): “The head circumference may be normal at birth, but during the first four years of life, an overgrowth of the brain is observed [5,6].”
Comparing symptoms of Autism Spectrum Disorders using the current DSM-IV-TR diagnostic criteria and the proposed DSM-V diagnostic criteria (2012, methodology): “…and colleagues (2004) findings indicated that in male children and adolescents, brain volume was larger for those with HFA compared to those with AS. Courchesne, Carper, and Akshoomoff (2003) conducted an investigation of brain growth in children diagnosed with AD (n = 17) and PDD-NOS (n = 5).”
Mapping early brain development in autism. (2007, positive): “New MRI and head circumference studies have given rise to a new hypothesis—autism involves two phases of early brain growth pathology (Courchesne et al., 2001, 2003; Courchesne and Pierce, 2005a): early brain overgrowth at the beginning of life and slowing or arrest of growth during early childhood…”
Neuroanatomic observations of the brain in autism: a review and future directions (2005, background): “Clinically, the head circumference of the autistic child has been said to be either normal or slightly small at birth but later increases in size during early to mid-childhood (Lainhart et al., 1997; Courchesne et al., 2003).”