Autism and Abnormal Development of Brain Connectivity

By Matthew K. Belmonte, G. Allen, A. Beckel-Mitchener, L. Boulanger, Ruth A. Carper, S. Webb. Journal of Neuroscience, 2004

1,267 citations recorded by the source corpus.

It has been said that people with autism suffer from a lack of “central coherence,” the cognitive ability to bind together a jumble of separate features into a single, coherent object or concept ([Frith, 1989][1]). Ironically, the same can be said of the field of autism research, which all too

Subfields: Cognitive Neuroscience, Education, Genetics

View Paper: https://www.semanticscholar.org/paper/96324abf1f6a688efe0689e52411ebdf0e076f79

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Citations in the corpus

Trouble at Rest: How Correlation Patterns and Group Differences Become Distorted After Global Signal Regression (2012, neutral): “…because it is precisely these sorts of comparisons that researchers are most interested in assessing when comparing clinical and control groups in terms of local and long-range correlation differences in RS-FMRI studies [see Belmonte et al. (2004) and Fox and Greicius (2010) for review/discussion].”
Normal Development of Brain Circuits (2010, background): “These findings may indicate the persistence of exuberant synapses and myelin or reduced apoptosis, and abnormal patterns of brain connectivity (Belmonte et al, 2004).”
Abnormalities of Intrinsic Functional Connectivity in Autism Spectrum Disorders (2009, positive): “Autism spectrum disorders (ASD), a set of debilitating neurodevelopmental conditions that impact social functioning, communication and are associated with restricted and repetitive interests and activities (APA, 1994), are often described as disorders of altered brain connectivity (Belmonte et al., ”
Network science of biological systems at different scales: A review. (2017, neutral): “[53] Belmonte MK, Allen G, Beckel-Mitchener A, Boulanger LM, Carper RA, Webb SJ.”
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits (2014, neutral): “The increase in basal dendrite spine density suggests an enhanced local excitatory connectivity, a feature of ASD (Belmonte et al., 2004) proposed to cause failure in differentiating signals from noise, prevent development of normal longrange cortical-cortical and cortical-subcortical…”
Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity (2009, background): “The idea at the neurological level that ASC involves an abundance of local short-range connectivity (Belmonte et al. 2004) may explain this cognitive style of identifying one specific link between two details.”
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities and core autism-related deficits (2011, positive): “, 2009) and there is increasing evidence of abnormal neural synchrony as a pathophysiological mechanism in ASD (Uhlhaas and Singer, 2006; Belmonte et al., 2004).”
Vision in autism spectrum disorders. (2009, background): “Other ideas at the neural level, in no particular order, include the absence of ‘‘top-down” neural control (Frith, 2003), malfunctioning social reward mechanisms based around the amygdala (Schultz, 2005), neural connectivity abnormalities (Belmonte et al., 2004; Minshew & Williams, 2007; Rippon, Bro”
Differences in White Matter Fiber Tract Development Present from 6 to 24 Months in Infants with Autism (2012, background): “Autism is increasingly considered a disorder characterized in part by aberrant neural circuitry (14, 15).”
Abnormal Brain Connectivity Patterns in Children with Global Developmental Delay Accompanied by Cognitive Impairment: A Resting-State EEG Study. (2025, unknown): “…may be related to reduced cognitive flexibility [50], highlighting the need to explore the neural mechanisms behind changes in network metrics in depth. γ -Band: Human γ -band activity has been related to a variety of functions ranging from perception and attention to memory and consciousness [51].”