Innate immune recognition of viral infection

By Taro Kawai, Shizuo Akira. Nature Immunology, 2006

1,878 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1d30df6d0ab35de85519ca3db7795618ba454e60

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Citations in the corpus

Toll-like receptors and innate immunity (2006, background): “Recent reports showed that hosts also have a mechanism to detect replicating viruses in the cytoplasm in a TLR-independent manner [101].”
Toll-like receptor function and signaling. (2006, background): “IFN-b stimulator 1 (IPS-1), also called mitochondrial antiviral signaling protein, virus-induced signaling adaptor, or CARD adaptor inducing IFN-b, is a critical adapter molecule that can interact with RIG-I/Mda5 through the homophilic interaction of their CARD-like domains.(5) IPS-1 activates NF-kB”
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection (2006, background): “dsRNA and dsDNA are known activators of innate immunity and stimulate type I interferon productio”
A cell biological view of Toll-like receptor function: regulation through compartmentalization (2009, background): “For example, some receptors (such as TLR3 and TLR4) induce both a pro-inflammatory and a type I interferon (IFN) response, whereas others (such as TLR2 and TLR5) induce only the pro-inflammatory respons”
Pattern recognition receptors and inflammation. (2010, background): “The CARDs of RLRs are responsible for triggering signaling cascades by interacting with the N-terminal CARD-containing adaptor IFN-b-promoter stimulator 1 (IPS-1) (also known as MAVS, CARDIF, or VISA) (Kawai and Akira, 2006) (Figure 3).”
The specific and essential role of MAVS in antiviral innate immune responses. (2006, background): “, IFN-a and IFN-b) and other proinflammatory cytokines through two distinct signaling pathways (Honda et al., 2005; Kawai and Akira, 2006; McWhirter et al., 2005; Seth et al., 2006).”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-phase activation of NF-kB andMAP kinases (Kawai and Akira, 2010).”
Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “RLRs are helicases that sense primarily viruses (8, 9).”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “For example, plasmacytoid dendritic cells (pDCs) and inflammatory monocytes have unique signaling pathways that govern antiviral responses that are probably absent in other cell type”
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections (2007, neutral): “Indeed, the activation of Dorsal and DIF could be mediated directly at the level of TISC, in a manner conceptually similar to the recently described activation of transcription factors of the IRF family by IRAK1 in mammal”
Activation of innate immune antiviral response by NOD2 (2009, background): “1782" language="eng" relation="no"> Innate immune antiviral responses are the first line of defense against viral infectio”