TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

By Xaralabos Varelas, Rui Sakuma, Payman Samavarchi-Tehrani, Raheem Peerani, B. Rao, J. Dembowy, Michael B. Yaffe, P. Zandstra, Jeffrey L. Wrana. Nature Cell Biology, 2008

697 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/164dac9c78d29c5461048437e1dc22df8328a95c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. K. Guan
2. S. Piccolo
3. G. Halder
4. Bin Zhao
5. Randy L. Johnson
6. M. Cordenonsi
7. H. Park
8. Jung-Soon Mo

In Molecular Biology

1. K. Guan
2. Bin Zhao
3. G. Halder
4. Randy L. Johnson
5. S. Piccolo
6. Duojia Pan
7. M. Cordenonsi
8. Xaralabos Varelas

Citations in the corpus

• The Hippo Signaling Pathway in Development and Disease (2019, background): “Early studies suggested that YAP/TAZ are required for ESCs to maintain pluripotency and self-renewal, with YAP activation preventing ESC differentiation even in differentiation medium (Lian et al., 2010; Varelas et al., 2008).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “YAP and TAZ were repeatedly isolated as binding proteins for Smads, key transducer of the TGF- and BMP signaling pathways (2, 207, 208).”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “Conversely, YAP and TAZ can control BMP/TGF-bdependent Smad signaling (Alarcón et al., 2009; Varelas et al., 2008).”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “(B) Upon mesendoderm specification, the TAZ/YAP-TEAD-OCT4 complex dissociates, allowing the TGFβ-induced SMAD2/3-SMAD4 complexes to activate the FOXH1 transcription factor, consequently driving mesendoderm gene expression.”
• The regulation of TGFβ signal transduction (2009, background): “TAZ, the nuclear Smad-tethering factor (Varelas et al., 2008).”
• Hippo signaling: growth control and beyond (2011, background): “, 2010), while Taz binding to the TGF signal transducing Smad2/3 complex couples it to the transcriptional machinery (Varelas et al., 2008).”
• The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. (2010, background): “Notably, TAZ has been reported to bind directly to Smad2/3, and may play a role in human ES cells (Varelas et al. 2008).”
• The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “Recently, the Hippo pathway has also emerged as a crucial regulator of pluripotency in vitro [80,81].”
• TGF-β Signaling from Receptors to Smads (2016, positive): “2002) and TAZ (Varelas et al. 2008).”
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. (2010, background): “genes, respectively, to maintain stem cell pluripotency (Varelas et al. 2008; Alarcon et al. 2009).”
• The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (2013, neutral): “However, unlike in the murine situation, this effect appears to be mediated by TAZ 51 .”