A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers

By M. Tsuge, Ryuji Hamamoto, F. P. Silva, Y. Ohnishi, K. Chayama, N. Kamatani, Yoichi Furukawa, Yusuke Nakamura. 2005

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In Molecular Biology

Citations in the corpus

Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells (2008, background): “Further investigations identified E2F1-binding elements in the 50 flanking region of SMYD3, and its expression was enhanced by elevated E2F1 that is frequently activated in human cancer by the inactivation of retinoblastoma protein 1 through its phosphorylation by cyclin-dependent kinases or an inte”
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents (2015, background): “Indeed, dysregulation of arginine and lysine methyltransferases have frequently been observed in human cancer [38–43], and these enzymes are now considered as emergent targets for anti-cancer drug development [14, 39, 44].”
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma (2018, unknown): “In 2003, SMYD3 (SET and MYND domain containing 3), a histone methyltransferase, was shown to stimulate HCC cell proliferation through its methyltransferase activity [11–15].”
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP (2015, background): “Accumulated evidence has indicated that methylation of arginine and lysine residues plays an important role in the regulation of many biological processes like phosphorylation does, and its deregulation is almost certainly involved in human tumorigenesis [14, 35-37].”
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “We previously reported that SMYD3, a histone methyltransferase, stimulates cell proliferation through its methyltransferase activity and plays a crucial role in human carcinogenesis [6-10].”
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, background): “Many reports have indicated that dysregulation of protein lysine methyltransferases and protein lysine demethylases has important roles in human tumorigenesis [32-37].”