Signalling pathways and molecular interactions of NOD1 and NOD2

By W. Strober, P. Murray, A. Kitani, Tomohiro Watanabe. Nature reviews. Immunology, 2006

889 citations recorded by the source corpus.

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori. Here, we focus on the molecular interactions between these NOD proteins and other intracellular molecules to elucidate the mechanisms by which NOD1 and NOD2 contribute to the maintenance of mucosal homeostasis and the induction of mucosal inflammation.

Subfields: Endocrinology, Small Animals, Surgery

View Paper: https://www.semanticscholar.org/paper/1a67c2ba8b35e73e8b188b241c99358df0320bea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. B. Sinha
2. F. Powrie
3. Martin J. Fraunholz
4. K. Maloy
5. S. Lebeer
6. Shizuo Akira
7. J. Vanderleyden

In Small Animals

1. B. Sinha
2. Martin J. Fraunholz
3. Shizuo Akira

In Surgery

1. B. Sinha
2. Martin J. Fraunholz
3. S. Lebeer
4. Shizuo Akira
5. J. Vanderleyden

Citations in the corpus

• A Proposed Classification of the Immunological Diseases (2006, background): “]. Specifically, the NOD2-associated mutations are thought to be linked to aberrant intracellular innate immune responses to bacterial peptidoglycan [”
• Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “NOD proteins and NLR proteins represent a class of intracellular receptors that share a conserved domain structure and sense a wide variety of PAMPs and other danger signals (78, 292).”
• Toll-like receptors and innate immunity (2006, background): “A missense point mutation in the human NOD2 gene is correlated with susceptibility to Crohn’s disease [4].”
• Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “Therefore, careful dissection of the molecular mechanisms involved in the interaction between TLRs and NOD2 and of their role in mucosal immunity should improve our understanding of the pathogenesis of inflammatory coliti”
• Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “The activation of cytosolic NOD-like receptors (NLRs) may also be important in maintaining barrier function, as mice lacking Nod1 or Nod2 , or bearing a Crohn's-disease-associated mutant allele of human NOD2 , showed defects in defensin secretion and increased susceptibility to DSS coliti”
• Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens (2010, background): “and intracellular nucleotide-binding oligomerization domain-containing protein (NOD)-like receptors (NLRs”
• Intracellular staphylococcus aureus: Live-in and let die (2012, positive): “Peptidoglycan binding leads to a conformation change in NOD proteins, which initiates the recruitment of ubiquitin ligases and kinases and ultimately results in nuclear translocation of NFκB and activator protein 1 and expression of inflammatory genes (reviewed in Strober et al., 2006).”