A PGC1–α–dependent myokine that drives brown–fat–like development of white fat and thermogenesis

By M. Ruth. 2012

1,629 citations recorded by the source corpus.

Subfields: Biochemistry, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/18e09666513254b4ddb039bd2ddf9961a533f741

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Citations in the corpus

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans (2014, methodology): “Nevertheless, we measured the levels of FT3, FT4, FGF21, cytokines (irisin, leptin, IL-6), and norepinephrine, which have been previously associated with BAT activation (8,10,30,31).”
Adipose tissue and adipocytes supports tumorigenesis and metastasis (2013, background): “In contrast, beige adipocytes further differentiate along the white adipocyte lineage [13,14].”
Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “FNDC5 (also known as FRCP2 and PeP) was then predicted to be a secreted protein that was expressed at a higher level in skeletal muscle post-exercise or with ectopic PGC-1a expression (Bostrom et al. 2012; Lecker et al. 2012).”
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. (2014, background): “, 2011), the myokine Irisin (Boström et al., 2012), and the prostaglandin synthesis enzyme cyclooxygenase (COX) 2 (Vegiopoulos et al.”
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis (2014, background): “Notably, these increases in IL4/IL13 gene expression and alternative macrophage activation in vivo were not observed with Irisin, a secreted form of Fndc5 that has been previously shown to stimulate adipose tissue thermogenesis via a direct action on adipocytes (Figure 5H) (Boström et al., 2012).”
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling (2014, background): “A previous study showed that irisin significantly improves glucose tolerance and insulin resistance in the mice fed with HFD (12); the mechanism of this effect, however, was unknown.”
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, positive): “Two novel myokines, irisin and meteorin-like (METRNL), are upregulated by the exerciseinduced PGC1α pathway and activate beige adipocyte development (57, 60).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “The PGC-1α-dependent myokine irisin, known for its browning effects (101), may also be involved in mediating effects of physical activity on the brain (98).”
Mitochondria: In Sickness and in Health (2012, background): “Another muscle-secreted cytokine, irisin, was recently shown to mediate the differentiation of white adipose cells to brown fat in response to exercise and PGC1alpha-induced mitochondrial biogenesis in skeletal muscle (Boström et al., 2012).”
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. (2013, background): “Irisin is a novel myokine, proteolytically processed from the product of the FNDC5 gene prior to being released into the circulation (10).”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, methodology): “Peripheral Delivery of FNDC5 by Adenoviral Vectors Increases Bdnf Expression in the Hippocampus We had previously shown that adenoviral overexpression of FNDC5 in the liver, a major secretory organ, increases circulating levels of irisin, the secreted form of FNDC5 (Bostrom et al., 2012).”