Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

By Rajesh R. Rao, Jonathan Z. Long, James P. White, Katrin J. Svensson, Jesse Lou, Isha Lokurkar, Mark P. Jedrychowski, J. Ruas, C. Wrann, James C. Lo and 6 more. Cell, 2014

917 citations recorded by the source corpus.

Summary Exercise training benefits many organ systems and offers protection against metabolic disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4) as a discovery tool, we report the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure. Increasing circulating levels of Metrnl stimulates energy expenditure, improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. Metrnl stimulates an eosinophil-dependent increase in IL-4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Importantly, blocking Metrnl actions in-vivo significantly attenuates chronic cold exposure-induced alternative macrophage activation and thermogenic gene responses. Thus, Metrnl links host adaptive responses to the regulation of energy homeostasis and tissue inflammation, and has therapeutic potential for metabolic and inflammatory diseases.

Subfields: Genetics, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/3c0371a0d66bec012d710a6e9a8f62cc7fda62ca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Physiology

In Rehabilitation

Citations in the corpus

Integrative biology of exercise. (2014, neutral): “The current list of potential myokines includes but is not limited to IL-8, IL-15, decorin, follistatin-like 1, fibroblast growth factor-21 (FGF21), irisin, chemokine CXC motif ligand-1 (CXCL-1) also known as KC (keratinocyte-derived chemokine), and meteorin-like (Metrnl) (Boström et al., 2012; Rao ”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “In 2014, Spiegelman’s group (141) identified meteorin-like (Metrnl), a circulating muscle-derived factor, that is induced in muscle after exercise.”
Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “, 2011); the myokines IL-6 (Pedersen and Febbraio, 2012) and meteorin-like (Rao et al., 2014); and the gut hormones FGF15/19 (Potthoff et al.”
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, positive): “Two novel myokines, irisin and meteorin-like (METRNL), are upregulated by the exerciseinduced PGC1α pathway and activate beige adipocyte development (57, 60).”
Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “On the other hand, METRNL promotes an eosinophil-dependent activation of M2 macrophages to elicit beige adipocyte biogenesis (Rao et al., 2014).”
Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, neutral): “This browning of scWAT by IL-33 was comparable in magnitude to that induced by the type 2 cytokines IL-4 or IL-13 (Figure 1C), which previously have been implicated in the development of beige fat (Qiu et al., 2014; Rao et al., 2014).”