Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
By M. Chondronikola, E. Volpi, E. Børsheim, Craig Porter, P. Annamalai, S. Enerbäck, Martin E. Lidell, M. Saraf, Sébastien M. Labbé, Nicholas M. Hurren and 6 more. Diabetes, 2014
732 citations recorded by the source corpus.
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear. To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT+) men and five BAT-negative (BAT−) men under thermoneutral conditions and after prolonged (5–8 h) cold exposure (CE). The two groups were similar in age, BMI, and adiposity. CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only. These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.
Subfields: Physiology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/b4f35c8c51da60400e9007dc35aff766d1b9c5ad
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In Physiology
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In Rehabilitation
Citations in the corpus
- Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “In fact, improvement in systemic glucose homeostasis and insulin sensitivity is associated with glucose uptake activity in adult human BAT (Chondronikola et al., 2014; Lee et al., 2014b).”
- Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, unknown): “Understanding BAT-mediated interor-gan communication would further uncover new roles for BAT in energy and glucose homeostasis.”