Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
By Yuan Zhang, Rui Li, Y. Meng, Shiwu Li, William Donelan, Yan Zhao, Lei Qi, Ming-Xiang Zhang, X. Wang, Taixing Cui and 2 more. Diabetes, 2014
718 citations recorded by the source corpus.
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose tissue (WAT) depots are readily convertible to a ‘‘brown-like’’ state, which is associated with weight loss. Irisin, a newly identified hormone, is secreted by skeletal muscles into circulation and promotes WAT “browning” with unknown mechanisms. In the current study, we demonstrated in mice that recombinant irisin decreased the body weight and improved glucose homeostasis. We further showed that irisin upregulated uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression. This effect was possibly mediated by irisin-induced phosphorylation of the p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal–related kinase (ERK) signaling pathways. Inhibition of the p38 MAPK by SB203580 and ERK by U0126 abolished the upregulatory effect of irisin on UCP-1. In addition, irisin also promoted the expression of betatrophin, another newly identified hormone that promotes pancreatic β-cell proliferation and improves glucose tolerance. In summary, our data suggest that irisin can potentially prevent obesity and associated type 2 diabetes by stimulating expression of WAT browning-specific genes via the p38 MAPK and ERK pathways.
Subfields: Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/31ad0403d914954e9b94d15aafe8be1d5dc4b302
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
In Physiology
- J. Hawley
- Steven P. Gygi
- B. Spiegelman
- James P. White
- C. Wrann
- S. Kajimura
- R. Scarpulla
- Christoph Handschin
Citations in the corpus
- Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis (2014, background): “We recently identified a PGC1a1-dependent membrane protein, Fndc5, which is proteolytically cleaved into a secreted polypeptide termed irisin, which preferentially induces UCP-1-positive cells or ‘‘browning’’ of theWAT in cell culture and in vivo (Boström et al., 2012; Wu et al., 2012; Zhang et al.,”