AP-1: a double-edged sword in tumorigenesis

By R. Eferl, E. Wagner. Nature Reviews. Cancer, 2003

2,241 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1898bf87f47840f50dd05e78f0955d58e263a149

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Citations in the corpus

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes (2012, background): “FOS and JUN, which constitute the AP-1 transcription factor, have been linked to both tumor progression and suppression [42].”
Signal integration by JNK and p38 MAPK pathways in cancer development (2009, background): “A major JNK target is the transcription factor AP1 , which is composed of Fos and Jun family member”
ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “c-Fos is a transcription factor that together with c-Jun make up one form of the AP1 (activating protein 1) transcription factors that regulate early transcriptional processes following the extracellular stimulation of cells [87].”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, neutral): “AP-1 is a molecule that regulates genes responsible for cell apoptosis and proliferation, such cyclin D1, p53, p21 , and p16 genes (66, 75, 282).”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “This induction is important for the proper progression of various cellular processes, including proliferation and differentiation and seems to be dysregulated within oncogenic transformation [96].”
Understanding MAPK Signaling Pathways in Apoptosis (2020, background): “AP-1 regulates a wide range of cellular processes, including cell proliferation, differentiation, cell survival, and apoptosis [20,21].”
Immunity, Inflammation, and Cancer (2010, neutral): “TNF-α activates both AP-1 and NF-κB transcription factors, but in the skin its tumor promoting effects are mediated by AP-1 (Eferl and Wagner, 2003), which was identified as a transcription factor whose activity is stimulated by the classic tumor promoter tetradecanoyl phorbol acetate (TPA) (Angel e”
Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “AP-1 are primarily dictated by the dimer composition of the AP-1 family proteins and their post-transcriptional and translational modifications [35].”