Long noncoding RNAs and human disease.

By Orly L. Wapinski, Howard Y. Chang. Trends in Cell Biology, 2011

1,910 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1860823cba47072beb88020d4bdadf1f83ccdd7d

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Citations in the corpus

Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “The prediction of lncRNA–disease associations is of great significance in biological, medical and other fields [214].”
LncTar: a tool for predicting the RNA targets of long noncoding RNAs (2015, positive): “we found that base pairing could play key roles in the lncRNA–mRNA interactions [8, 14].”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “Furthermore, there are a number of studies that have shown many lncRNAs are dysregulated in various human diseases and disorders, although it is not yet clear if these lncRNAs are causal or symptomatic of the disease state (15,16).”
LincRNA-p21 suppresses target mRNA translation. (2012, background): “With rising recognition that lncRNAs play pivotal roles in disease processes (Wapinski and Chang, 2011), other proteins regulated by the orchestrated influence of RBPs, lncRNAs, and miRNAs are likely to emerge.”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “These genetic changes to lncRNA sequences link to numerous diseases [2,105,106].”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “Moreover, the deregulation of lncRNAs has been related to different human diseases, including cancer and cardiovascular and neurodegenerative diseases [18, 19].”
Genome regulation by long noncoding RNAs (2012, background): “Underscoring the importance of lncRNAs’ regulatory roles is their emergence as key players in the etiology of several disease states (118).”
Neural tissue engineering options for peripheral nerve regeneration. (2014, background): “In terms of their composition, miRNAs belong to a class of small noncoding RNAs, while another class of long noncoding RNAs (lncRNAs), each of which contain nucleotides ranging from 200 to more than 100,000 [215], are found to be highly expressed in the brain [216,217], serving as mediators of mRNA ”
On the classification of long non-coding RNAs (2013, background): “44 Moreover, a considerable number of lncRNAs are 3' polyadenylated, 5' capped, multi-exonic 2,4,20 and exhibit transcriptional activation activity similar to that of mRNAs.”
LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases (2018, background): “Large number of studies have indicated that long noncoding RNAs (lncRNAs, >200 nt in length) are highly associated with the progression of a wide variety of diseases (1,2).”
NONCODEV5: a comprehensive annotation database for long non-coding RNAs (2017, background): “Conformational changes of the RNA structure, expression levels and lncRNA-binding proteins can all contribute to dysfunction, including cancer and neurodegenerative disorders (26).”
Molecular mechanisms of long noncoding RNAs (2011, background): “…RNA molecules greater than 200 nt in length—are poorly conserved and regulate gene expression by diverse mechanisms that are not yet fully understood (Bernstein and Allis, 2005; Bracken and Helin, 2009; Faghihi and Wahlestedt, 2009; Mercer et al., 2009; Whitehead et al., 2009; Wilusz et al., 2009).”