LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases
By Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong. Nucleic Acids Res., 2018
496 citations recorded by the source corpus.
Abstract Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining their underlying molecular mechanisms. In 2013, we presented the first release of LncRNADisease, representing a database for collection of experimental supported lncRNA-disease associations. Here, we describe an update of the database. The new developments in LncRNADisease 2.0 include (i) an over 40-fold lncRNA-disease association enhancement compared with the previous version; (ii) providing the transcriptional regulatory relationships among lncRNA, mRNA and miRNA; (iii) providing a confidence score for each lncRNA-disease association; (iv) integrating experimentally supported circular RNA disease associations. LncRNADisease 2.0 documents more than 200 000 lncRNA-disease associations. We expect that this database will continue to serve as a valuable source for potential clinical application related to lncRNAs. LncRNADisease 2.0 is freely available at http://www.rnanut.net/lncrnadisease/.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/45a275ddab926f044ab6b3d643a0b699db1ef4ca
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Citations in the corpus
- Non-coding RNAs in disease: from mechanisms to therapeutics (2023, unknown): “Several databases, such as The Human MicroRNA Disease Database 101 for miRNAs and LncRNADisease 102,103 for lncRNAs and circRNAs, can be useful resources for up-to-date information on disease-related ncRNAs.”
- The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “CSCD [120] and MiOncoCirc [17] are cancer-specific circRNA databases aiming to facilitate the functional study of cancer-specific circRNAs, while HDncRNA [121] and LncRNADisease [122] store disease-associated ncRNAs including circRNAs.”