LincRNA-p21 suppresses target mRNA translation.

By Je-Hyun Yoon, K. Abdelmohsen, S. Srikantan, Xiaoling Yang, J. Martindale, Supriyo De, Maite Huarte, M. Zhan, K. Becker, M. Gorospe. Molecules and Cells, 2012

940 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4e0d534a2f2f8d863bca96b6c53f601aef4ee27c

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Citations in the corpus

LncRNA: a link between RNA and cancer. (2014, neutral): “selectively lower their translation [37].”
Long Non-coding RNAs in the Cytoplasm (2016, background): “It is more abundant in cytoplasm compared to nucleus, known to co-distribute with ribosomes [43].”
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 (2017, positive): “coding (lnc)RNAs, including LINCRNAP21, HOTAIR, and RMRP, influencing their stability or subcellular localization.(6,8,9)”
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “In contrast, lincRNA-p21 inhibits translation by recruiting the translational repressor Rck [95].”
Long noncoding RNAs: Cellular address codes in development and disease (2013, positive): “In the absence of HuR, lincRNA-p21 is stable and interacts with the mRNAs CTNNB1 and JUNB and translational repressor Rck, repressing the translation of the targeted mRNAs (Yoon et al., 2012) (Figure 4D).”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “Additionally, it has been reported that lincRNA-p21 associates with polysome-bound b-catenin and JunB mRNAs in a manner dependent on the general translation repressor Rck, leading to decreased polysome number, and thus translation, of these mRNAs (Yoon et al. 2012).”
A census of human RNA-binding proteins (2014, positive): “Cytoplasmic ncRNAs can modulate mRNA translation (Yoon et al., 2012).”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “A study by Yoon and colleagues in 2012 shows a posttranscriptional function of lincRNA-p21 as a modulator of translation [95].”
Multiple knockout mouse models reveal lincRNAs are required for life and brain development (2013, neutral): “pluripotency) and regulating cell cycle and translation (Tsai et al., 2010; Guttman et al., 2011; Wang et al., 2011; Yoon et al., 2012).”