The multidimensional mechanisms of long noncoding RNA function

By F. Marchese, Ivan Raimondi, Maite Huarte. Genome Biology, 2017

885 citations recorded by the source corpus.

A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes.

Subfields: Cancer Research, Endocrinology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f3d5ebfeaf185aec9b8eddafb6c9c758afccf96

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Pieter Mestdagh
2. Jo Vandesompele
3. Lennart Martens
4. Pieter-Jan Volders

Citations in the corpus

• LNCipedia 5: towards a reference set of human long non-coding RNAs (2018, background): “First regarded as transcriptional noise, lncRNAs are now known to exhibit diverse functions through a wide array of mechanisms (2,3).”