Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

By Eric C. Lai. Nature Genetics, 2002

1,494 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1833c6b53700d55b251fbcf03812a84eeb5546bd

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Citations in the corpus

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. (2006, background): “This portion of the guide strand is analogous to the ‘‘seed’’ region at the 59 end of a microRNA that is implicated in gene regulation by inhibition of translation and/or mRNA degradation (Lai 2002; Lewis et al. 2003; Stark et al. 2003; Yekta et al. 2004; Bagga et al. 2005).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Translational repression is a consequence of the miRNA/RISC complex binding to a target site in the 30-UTR of the targeted mRNA that is complementary to the 50-miRNA seed sequence, but usually not completely complementary along the entire miRNA/mRNA complex (Lai, 2002).”
Prediction of mammalian microRNA targets. (2003, background): “UTRs—that is, to the extent that the signal exceeds the noise, these identified UTRs posttranscriptional regulation or are known miRNA targets (Lai, 2002; Stark et al., 2003).”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “There are other miRNAs that have complementarity to several classes of conserved sequences known to mediate negative post-transcriptional regulation (Lai 2002), and further investigation is needed to understand the role of miRNAs in these regulatory pathways.”
Regulation of miRNA expression during neural cell specification (2005, background): “Lai (2002) first suggested that a group of D. melanogaster miRNA might regulate proneural transcription factors that act in the Notch pathway.”
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. (2002, background): “There is also reason to speculate that the Drosophila ago1 neuronal defects could result from miRNA-mediated regulation , as several miRNAs with complementarity to negative regulatory elements in the 3ЈUTRs of genes that regulate neuronal development have been identified (Lai 2002).”
Fragile X-related protein and VIG associate with the RNA interference machinery. (2002, background): “Both to address the underlying mechanism of siRNA-guided degradation and to investigate the degree to which the mechanisms of siRNA and miRNA-mediated silencing overlap, we have sought to determine the composition of RNAi-effector complexes.”
Perspective: machines for RNAi. (2005, background): “The preeminent role of these bases was first proposed by Lai (2002), who noted that bases 2–8 of many miRNAs were complementary to conserved sequence elements in the 3 untranslated regions (UTRs) of post-transcriptionally repressed mRNAs in flies.”
Canalization of development by microRNAs (2006, background): “Intriguingly, E[spl]-C genes are directly regulated by multiple miRNA”
microRNA target predictions in animals (2006, background): “elegans for two miRNAs, all located in the 3′ untranslated regions (UTRs) of mRNAs); (ii) the initial observation of Eric Lai that known posttranscriptional regulatory motifs in 3′ UTRs, such as the K-box, are perfectly complementary to the 5′ end of some fly miRNA”