Canalization of development by microRNAs

By E. Hornstein, Noam Shomron. Nature Genetics, 2006

605 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ae0ec46682729cbc34c5180d20337c9cae6556e

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Citations in the corpus

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. (2008, neutral): “MicroRNAs could act either by regulating a specific set of critical developmental genes or by reinforcing gene-expression programs through suppression of transcriptional noise (Bartel and Chen, 2004; Hornstein and Shomron, 2006; Yekta et al., 2004).”
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs (2014, background): “Therearemanyindicationsthattheactionsof miRNAs and TFs are tightly integrated (Cui et al. 2006; Hornstein and Shomron 2006; Zhou et al. 2007), and ISMARA’s incorporation of miRNA regulation allows for the automated identification of regulatory interactions between TFs and miRNAs as demonstrated by…”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “While type I circuits may seem counterintuitive and its functional significance has not been fully characterized, type I circuits have the potential to provide a host of regulatory and signal processing functions (Hornstein and Shomron, 2006), such as the fine-tuning and maintenance of protein stead”
MicroRNA control of signal transduction (2010, background): “This is a highly redundant system, in which families of related miRNAs (miR-2, miR-4, miR-7, miR-11 and miR-79 ) promiscuously target a family of related mRNAs, preventing aberrant deployment of Notch-mediated developmental programme”
Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network (2007, background): “For example, this mechanism could be useful in determining developmental fate in differentiation boundaries as also suggested by [22,23,36].”
microRNA regulation of inflammatory responses. (2012, background): “Furthermore, miRNAs allow for more consistent protein expression levels between cells and species by limiting transcriptional noise, and this is hypothesized to have allowed for more complex phenotypes to evolve (12).”
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. (2008, background): “enhance the functionality and robustness of gene networks (25, 26).”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, background): “In general, the fact that many miRNAs fine-tune targets or lend robustness to pathway output has led to the hypothesis that miRNAs are often exploited to canalize developmental trait”
The control of developmental phase transitions in plants (2011, background): “This may be achieved by repressing leaky transcripts in the case of high miRNA to target ratios or to buffer against fluctuations in target expression in the case of co-expression at intermediate levels (Hornstein and Shomron, 2006).”
Metazoan MicroRNAs (2018, background): “With this modular, combinatorial regulatory pathway at its disposal, evolution can more easily generate complex, highly connected regulatory networks required to robustly cope with environmental, genetic, or stochastic contingencies (Hornstein and Shomron, 2006).”
Roles for microRNAs in conferring robustness to biological processes. (2012, positive): “…a trait that is canalized presents itself consistently among different individuals of a species in spite of environmental or genetic perturbations (Hornstein and Shomron, 2006). miRNAs may contribute to canalization by reducing random fluctuations in target gene expression, stabilizing signaling…”
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 (2009, background): “Finally, our studies provide experimental support for a proposed role for miRNA-dependent gene regulation in ensuring robustness of the cellular phenotypes (Hornstein and Shomron, 2006).”
MicroRNA and cancer (2012, background): “As such,miRNAmayserve to increase the precision of gene expression by dampening the production of proteins being expressed outside their physiologically optimal boundaries (Herranz and Cohen, 2010; Hornstein and Shomron, 2006; Levine et al., 2007).”