Molecular imaging of cancer with positron emission tomography

By Sanjiv Sam Gambhir. Nature Reviews. Cancer, 2002

1,654 citations recorded by the source corpus.

Subfields: Cancer Research, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/1804c75cb9fedd74d807489d73739a06ddc685d3

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In Cancer Research

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

A review of imaging techniques for systems biology (2008, background): “By using radioactive tracers, threedimensional images can be reconstructed to show the concentration and locations of metabolic molecules of interest [2].”
Inferring Pathway Activity toward Precise Disease Classification (2008, background): “Constitutively up-regulated glycolysis has been observed in most primary and metastatic cancers and further explored to develop potential therapeutic targets [36–38].”
ATP citrate lyase inhibition can suppress tumor cell growth. (2005, background): “Many human cancers display a high rate of aerobic glycolysis (Warburg, 1956), a phenomenon that is exploited in 18-F-2deoxyglucose positron emission tomography (FDG-PET) imaging for the detection of primary and metastatic tumors (Gambhir, 2002).”
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia (2011, methodology): “Adapted with permission from Macmillan Publishers Ltd: Nature Reviews Cancer, Gambhir, copyright 2002 [5].”
Molecular imaging in living subjects: seeing fundamental biological processes in a new light. (2003, methodology): “This is because drug development shares many features in common with molecular imaging probe development, and the two fields likely will continue to influence each other (Gambhir 2002).”
Molecular imaging in drug development (2008, background): “This cannot act as a substrate for further glycolysis and so rapidly accumulates in cells that have increased activity of hexokinase and increased glucose transporter levels, including tumour cells (Warburg effect”
Regulation of cancer cell metabolism (2011, background): “Accordingly, there is now a substantial body of useful clinical data regarding the importance of glucose as a fuel for malignancie”
Targeting metabolic transformation for cancer therapy (2010, methodology): “This is particularly evident in images recorded using [ 18 F]-fluorodeoxyglucose positron emission tomography (FDG-PET), in which tumours often appear as PET-positive as some of the most metabolically active organs (such as the brain and heart”
Acid-mediated tumor invasion: a multidisciplinary study. (2006, background): “Fluorodeoxyglucose-positron emission tomography imaging has shown that the vast majority of human cancers exhibit significantly increased glucose flux compared with normal tissue (1, 2).”
Metformin and the gastrointestinal tract (2016, methodology): “PET-CT is commonly used for the diagnosis, staging and monitoring of the response to treatment, of certain cancers [32].”
Glycans in cancer and inflammation — potential for therapeutics and diagnostics (2005, background): “To date, the field of molecular imaging has focused on protein-based markers that are targeted with antibody conjugates, receptor ligands or enzyme substrates/inhibitor”
Drug penetration in solid tumours (2006, background): “However, at present the sub-mm resolution of MRI and mm resolution of PET is insufficient to detect the microregional variations in drug concentration that occur within tumour”
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. (2007, background): “It is this phenomenon that now constitutes the physiological basis for [(18)F]fluorodeoxyglucose positron emission tomography (FDGPET) that is used for cancer diagnosis and monitoring therapeutic responses (13).”
Why do cancers have high aerobic glycolysis? (2004, positive): “However, interest in tumour metabolism has been rekindled, mainly because of the widespread clinical application of the imaging technique positron-emission tomography (PET) using the glucose analogue tracer 18 fluorodeoxyglucose (FdG”