Acid-mediated tumor invasion: a multidisciplinary study.

By Robert A. Gatenby, E. T. Gawlinski, A. Gmitro, B. Kaylor, Robert James Gillies. Cancer Research, 2006

743 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Hepatology

View Paper: https://www.semanticscholar.org/paper/da57cf7622111c058c7adc9b1aeb68b1adb3d57d

How researchers see this paper

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In Biomedical Engineering

Robert James Gillies

In Cancer Research

In Hepatology

Eyal Gottlieb

Citations in the corpus

Cysteine cathepsins: multifunctional enzymes in cancer (2006, background): “Mechanisms that induce secretion, such as peritumoral acidificatio”
A microenvironmental model of carcinogenesis (2008, background): “In addition, as another example of the multibarrier effect, invasion might also be promoted by upregulation of glycolysis and microenvironmental acidificatio”
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases (2009, methodology): “This has been formulated as the acid-mediated invasion hypothesis, wherein tumor-derived acid is excreted into the surrounding parenchyma, leading to degradation of the surrounding extracellular matrix (5).”
Targeting metabolic transformation for cancer therapy (2010, background): “Targeting tumour acidification may have more than one benefit: in the short term it will inhibit glycolytic energy production, but in the longer term it may well inhibit tumour cell invasio”
Acidity generated by the tumor microenvironment drives local invasion (2013, background): “lular matrix, possibly through the release and activation of proteolytic enzymes (7, 16).”
Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “This has been shown both theoretically (11) and empirically using window chambers (50).”
Mathematical Models of Avascular Tumor Growth (2007, neutral): “Data shown for different angles drawn from tumor center [91].”
The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “Tumor-adjacent blood vessels may be affected by the tumor microenvironment as the abnormal chemical composition extends several millimeters into the surrounding tissue (136, 137), but it is also possible that decreases in downstream resistance affect the tumor feed arteries as they experience sustai”
Function of alternative splicing. (2005, neutral): “Most tumors rely on anerobic glycolysis for their energy requirements, which acidifies the surrounding media (Gatenby et al., 2006).”
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Intriguingly, an acid concentration gradient from the center to the outside of the tumor tissue, which naturally forms the metastatic directionality, mediates cell mobility and invasion [290, 291].”
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis (2007, background): “As prolonged exposure of normal cells to an acidic microenvironment results in necrosis or apoptosis, constitutive upregulation of glycolysis requires additional adaptation of tumour cells to extracellular acidosi”