Targeting metabolic transformation for cancer therapy

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Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “Nonetheless, some of the first chemotherapeutic agents developed – nucleoside analogues referred to as antimetabolites – target nucleotide biosynthesis through the direct inhibition of enzymes used in DNA synthesis (71), and have remained a common and effective component of treatment regimens admini”
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “…for increased glucose uptake and catabolism via aerobic glycolysis or the PPP and are strongly implicated in tumorigenesis (O’Donnell et al., 2006; Tennant et al., 2010)— were elevated during hypoxia in SIRT3 KO MEFs and SIRT3 knockdown cells relative to control cells (Figure 3D; Figure S3A).”
Lactate: a metabolic key player in cancer. (2011, background): “Tennant and colleagues (35) compiled an impressive number of trials in clinical oncology up to phase III based on manipulating tumor”
Targeting cancer metabolism: a therapeutic window opens (2011, background): “Ras, PI(3)K and mTOR signalling controls tumour cell growth.”
Otto Warburg's contributions to current concepts of cancer metabolism (2011, methodology): “As such, we are poised to witness the clinical benefits of Warburg's contributions in the next 5 to 10 years, almost 100 years after his initial observation”