Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
By Aude Carreau, Bouchra El Hafny-Rahbi, A. Matejuk, C. Grillon, C. Kieda. Journal of Cellular and Molecular Medicine, 2011
1,200 citations recorded by the source corpus.
• Introduction ‐ Imaging of hypoxic areas ‐ Hypoxia markers ‐ Positron emission tomography (PET) ‐ Near‐infrared spectroscopy (NIRS) ‐ Magnetic resonance spectroscopy (MRS) ‐ Electron paramagnetic resonance spectroscopy (EPR) • Oxygen partial pressure measurement ‐ Polarographic sensor ‐ Optical sensor ‐ Mass spectrometry • What does tumour hypoxia mean? • Small molecules and hypoxia ‐ Chemotherapeutic drugs ‐ Radiation sensitizers: the nitroimidazoles ‐ Hypoxia prodrugs: tirapazimine and anthraquinone ‐ pO2 modulator: myo‐inositol trispyrophosphate (ITPP) ‐ Hypoxia mimetics: dimethyloxallyl glycine, desferrioxamine and metal ions • What does physioxia mean? ‐ From air to blood ‐ In brain ‐ In lungs ‐ In skin ‐ In intestinal tissue ‐ In liver ‐ In kidney ‐ In muscle ‐ In bone marrow ‐ In umbilical cord blood ‐ To summarize physioxia • Cellular and molecular consequences of physioxia versus normoxia and hypoxia ‐ Hypoxia inducible factors actions ‐ Role of microRNAs in hypoxia‐dependent regulations ‐ Cell adhesion molecules: their regulation by oxygen partial pressure ‐ Soluble molecules: example of angiogenin • Conclusion
Subfields: Biomedical Engineering, Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/885e1ada8c4bf03734ac447aaf53d5d4999b2570
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Citations in the corpus
- Colonocyte metabolism shapes the gut microbiota (2018, background): “bottom indicates oxygen (O2) levels, which are between 3% and 10% in normoxic tissue (85).”
- Depletion of butyrate-producing Clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella (2016, background): “When the pathogen enters host tissue, it encounters an oxygen partial pressure (pO2) of 23–70 mmHg (3%–10% oxygen), which is considerably lower than the atmospheric pO2 of 160 mmHg (21% O2) (Carreau et al., 2011).”
- Hypoxia-induced angiogenesis: good and evil. (2011, background): “For example, arterial blood has a normal pO 2 of 14%, the myocardium has a pO 2 of 10%, and most tissues have a pO 2 of ~5%.(4) However, cartilage, bone marrow, and thymus have domains that are naturally at or below 1% O 2 .”