HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

By H. Korkaya, Amanda K. Paulson, F. Iovino, M. Wicha. Oncogene, 2008

596 citations recorded by the source corpus.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/c340b7a541b7bab69c56bff959c6cab34b30b484

How researchers see this paper

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In Oncology

1. Suling Liu
2. M. Wicha
3. P. Dirks
4. Jane E. Visvader

Citations in the corpus

• Early dissemination seeds metastasis in breast cancer (2016, unknown): “Consistent with previous reports on HER2-stimulated stemness 19,20 Balb-NeuT-derived samples generated significantly higher numbers of spheres than controls (Figure 2b).”
• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Several recent studies suggested that the survival benefit of trastuzumab (Herceptin; Genentech/Roche) — a monoclonal antibody specific for receptor tyrosine protein kinase ERBB2 (also known as HER2) — might relate to its ability to target breast tumour-initiating cell”
• Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts (2013, result): “The preponderance of ALDH-expressing CSCs is most pronounced in HER2+ breast cancers.”