Crosstalk between apoptosis, necrosis and autophagy.
By V. Nikoletopoulou, Maria E. Markaki, K. Palikaras, Nektarios Tavernarakis. Biochimica et Biophysica Acta, 2013
1,332 citations recorded by the source corpus.
Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.
Subfields: Epidemiology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bd618fd190e2abe36e16e8a5f36912b7259ac1ca
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Citations in the corpus
- Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, neutral): “cesses [220].”
- Neuronal Cell Death. (2018, positive): “Ischemia initiates apoptosis in the penumbra; however, if apoptotic signaling is compromised, affected cells may still die by necro(pto)sis (409, 506).”
- The role of BCL-2 family proteins in regulating apoptosis and cancer therapy (2022, background): “Of these, chemotherapy is currently one of the most effective, despite its many side effects (2), and smallmolecule inhibitors are a representative strategy for cancertargeted therapy.”