Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

By Kelvin C. Luk, Victoria M. Kehm, J. Carroll, Bin Zhang, Patrick O’Brien, John Q. Trojanowski, V. Lee. Science, 2012

2,419 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/1463d4511a94fcd7affbb4c9f4dd8f4b9a7afbf3

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In Cellular and Molecular Neuroscience

1. T. Kam
2. M. Mouradian
3. V. Dias
4. H. Ko
5. Viviana Gradinaru
6. E. Junn
7. Nikhil Panicker

In Neurology

1. M. Mouradian
2. V. Dias
3. H. Ko
4. Edward A. Fon
5. E. Junn
6. Gian-Luca McLelland
7. M. Hasegawa
8. H. McBride

Citations in the corpus

• Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, neutral): “Second, inoculation of rodent and primate brain with either fragments of fibrillar alpha-synuclein or proteins derived from human LP can spread and induce neurodegeneration.(7,83,84) Although there is no doubt that proteins can spread from one neuron to the next in vitro or in models inoculated with”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “A critical process that leads to the progressive neuropathology in PD is the prion-like trans-neuronal propagation of alpha-synuclein [292, 293].”
• Prion-like spreading of pathological α-synuclein in brain (2013, background): “Luk et al. (2012a) showed that only inoculation of synthetic mouse -synuclein fibrils into wild-type mouse brain induced synuclein pathology.”
• Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, background): “Our preliminary studies comparing mouse and human a-syn PFF (Figure S3) indicate that human a-syn PFF is not as capable as mouse a-syn PFF in spreading, which is consistent with the finding that mouse a-syn PFF are substantially more effective than human a-syn PFF in the intrastriatal mouse model (L”
• A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, positive): “Secretion and cell-to-cell transfer of a-synuclein has been shown both in cells and in vivo (Lee et al, 2004, 2005, 2008a,b; Desplats et al, 2009; Luk et al, 2012a,b), and exosomes constitute a proposed method of propagation (Emmanouilidou et al, 2010; Kong et al, 2014; Lee et al, 2014).”