Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice.

By Jianping Ye, Zhanguo Gao, Jun-yi Yin, Qing He. American Journal of Physiology. Endocrinology and Metabolism, 2007

904 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Mechanisms of insulin resistance in obesity (2013, background): “Our study suggests that local hypoxia may contribute to the inflammatory response in adipose tissue [106].”
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “When hypoxia occurs in the adipose tissue, the expression levels of angiogenic factors and inflammatory response-associated genes are upregulated (86, 88, 89).”
Obesity as a Major Risk Factor for Cancer (2013, background): “Oxygen levels in the WAT of obese mice are considerably lower than those of lean mice [106], and adipose tissue hypoxia may contribute to cancer risk.”
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, methodology): “The whole cell lysate was prepared in a lysis buffer with sonication as described elsewhere (16).”
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “At the same time, the increased adipocyte size requires oxygen to diffuse over longer distances prior to reaching adipocyte mitochondria; this is evident by a decreased partial oxygen pressure (20 mmHg versus 40 mmHg) in obese versus lean mice, respectively (20, 37, 53).”