Myofibroblasts and mechano-regulation of connective tissue remodelling

By J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, Robert A. Brown. Nature reviews. Molecular cell biology, 2002

4,316 citations recorded by the source corpus.

Subfields: Biomaterials, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/10be099ffbb1461112649343e364a8e0eb37c3a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Rehabilitation

In Surgery

Citations in the corpus

Skin Acute Wound Healing: A Comprehensive Review (2019, neutral): “This process is repeated by other local MFs and the remodeling of small sections of the ECM produces wound contraction [41, 156].”
TGF-β signaling in fibrosis (2011, background): “The myofibroblast phenotype is characterized by formation of gap junctions and by the acquisition of a contractile apparatus with associated contractile proteins, such as α-SMA and non-muscle myosin (52).”
Formation and function of the myofibroblast during tissue repair. (2007, background): “We have recently proposed the term ‘‘proto-myofibroblast’’ to discriminate such activated fibroblasts from quiescent fibroblasts that are devoid of any contractile apparatus in most intact tissues (Tomasek et al., 2002).”
Cellular and molecular mechanisms of fibrosis (2008, background): “TGFβ1, in turn, augments the production of interstitial collagens, fibronectin and proteoglycans by cardiac myofibroblasts [2].”
Myocardial remodeling after infarction: the role of myofibroblasts (2010, background): “Myofibroblast differentiation after MI Under normal circumstances, resident cardiac fibroblasts have no contractile microfilaments or stress fibers, exhibit few or no actin-associated cell–cell and cell–matrix contacts and produce minimal amounts of ECM”
Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “In addition, mechanically stressed dermal fibroblasts have been shown to differentiate into myofibroblasts expressing-smooth muscle actin [119].”
Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth (2015, background): “These myofibroblasts acquire de novo expressed α-SMA, contractile stress fibers, and the ED-A splice variant of fibronectin [5,7].”
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression (2010, background): “TGF- is widely acknowledged to play a key role in driving fibrogenesis through its effects on activation of fibroblasts to myofibroblasts and stimulation of matrix synthesis (Tomasek et al., 2002).”
Matrix elasticity directs stem cell lineage specification. (2006, background): “…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044”