Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth
By Kazuyoshi Shiga, M. Hara, T. Nagasaki, Takafumi Sato, Hiroki Takahashi, H. Takeyama. Cancers, 2015
728 citations recorded by the source corpus.
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.
Subfields: Mechanical Engineering
View Paper: https://www.semanticscholar.org/paper/5e69af6f2ccfaceb9762b59f8ef9ae3f80b67eb4
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Citations in the corpus
- The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “In addition to the blood vessels and immune cells considered below, this stroma contains a large number of cancerassociated fibroblasts (CAFs) that not only shape the tumor architecture but also contribute to the tumor-protective niche that promotes cancer progression and treatment resistance (105).”
- Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2019, background): “05) was a unique feature of the CD8− inflamed tumor subtype (Figures 6A, 6B, and S6E; Shiga et al., 2015; Ziani et al., 2018).”
- Gastric cancer: a comprehensive review of current and future treatment strategies (2020, background): “pylori–induced gastric carcinogenesis in people as well as having the ability to stimulate neighboring CAFs towards participating in the Warburg effect [106, 107].”