Matrix elasticity directs stem cell lineage specification.

By A. Engler, Shamik Sen, H. Sweeney, Dennis E. Discher. Cell, 2006

13,059 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c3f10959d26d0ba0165a1e6301366ad55548baa3

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Citations in the corpus

Physics of adherent cells (2013, background): “In particular, it was found that skeletal muscle cells differentiate optimally on substrates with rigidities of 11 kPa (Engler et al., 2004b) and that stem-cell fate strongly depends on substrate rigidity (Engler et al., 2006).”
Recent advance in surface modification for regulating cell adhesion and behaviors (2020, background): “prepared polyacrylamide (PA) gels with different mechanical properties and studied the relationship between the spread area of smooth muscle cells and the elastic modulus of matrix [36].”
Mechanical control of tissue and organ development (2010, background): “Interestingly, cells preferentially differentiate into distinct cell types (e.g. neuron versus bone or muscle) when cultured on ECMs with a mechanical stiffness that is most similar to that of the respective in vivo tissue (Engler et al., 2006).”
Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells. (2009, background): “Combined with the spectroscopic data, these rheological data suggested that there are complex relationships between molecular composition, supramolecular organization and hydrogel characteristics; further understanding of the relationships may open up opportunities to match various hydrogels to spec”
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression (2010, background): “…important molecular players have emerged, including integrins (Paszek et al., 2005; Friedland et al., 2009), focal adhesion proteins such as FAK (Pelham and Wang, 1997; Paszek et al., 2005; Assoian and Klein, 2008), and cytoskeletal tension driven by the action of myosin II (Engler et al., 2006).”